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Y Combinator AI portfolio in San Francisco

The most prolific seed accelerator in the world, batch class twice a year. Filtered to AI companies headquartered in San Francisco.

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Built from a search like: “Y Combinator-backed AI companies in San Francisco”

Ranked by current headcount across Y Combinator-backed AI companies in San Francisco. Refreshed daily.

  1. 1
    Culture Biosciences· South San Francisco, California, United States
    • Series C
    • 69 employees
    • Founded 2016
  2. 2
    OpenAI· San Francisco, California, United States
    • Series unknown
    • 9.4k employees
    • Founded 2015
  3. 3
    Verge Labs· San Francisco, California, United States
    • Series C
    • 26 employees
    • Founded 2015
  4. 4
    Atomwise· San Francisco, California, United States
    • Series D
    • 16 employees
    • Founded 2012
  5. 5
    Shasqi· San Francisco, California, United States
    • Grant
    • 28 employees
    • Founded 2015
Reveal 39 more·100 free credits, no card

Y Combinator-backed AI companies in San Francisco

The list above ranks Y Combinator-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 44 matching companies in our index, you can see exactly where Y Combinator’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Y Combinator AI world in San Francisco.

Refolk converts this list into a live search. Ask for “Y Combinator AI companies in San Franciscohiring senior engineers” or “founders of Y Combinator-backed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Y Combinator, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Sun, 21 Jun 2026 03:08:14 GMT

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