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Y Combinator portfolio AI companies

The most prolific seed accelerator in the world, batch class twice a year. Filtered to companies in AI.

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Built from a search like: “Y Combinator-backed AI companies”

Ranked by current headcount across Y Combinator-backed AI companies. Refreshed daily.

  1. 1
    OpenAI· San Francisco, California, United States
    • Series unknown
    • 9.4k employees
    • Founded 2015
  2. 2
    BillionToOne· Menlo Park, California, United States
    • Series D
    • 796 employees
    • Founded 2016
  3. 3
    Ginkgo Bioworks· Boston, Massachusetts, United States
    • Grant
    • 539 employees
    • Founded 2009
  4. 4
    Opentrons Labworks Inc.· New York, New York, United States
    • Series D
    • 194 employees
    • Founded 2014
  5. 5
    54gene· Nigeria
    • Convertible note
    • 115 employees
    • Founded 2019
Reveal 136 more·100 free credits, no card

Y Combinator’s AI portfolio

The list above ranks Y Combinator-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 141 matching companies in our index give you a quick read on where Y Combinator has gone deepest in the AI space.

Y Combinator’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives - and they show up in AI talent pools across the next decade.

Refolk converts this list into a live search. Ask for “Y Combinator AIcompanies hiring senior engineers” or “founders of Y Combinator-backed AIcompanies” and Refolk returns a fresh ranked shortlist.

How this list is built

Refolk pulled AI companies whose disclosed Crunchbase investor list includes Y Combinator, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes once a day.

Last refreshed: Sun, 21 Jun 2026 08:22:33 GMT

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