Y Combinator portfolio AI companies
The most prolific seed accelerator in the world, batch class twice a year. Filtered to companies in AI.
- InvestorY Combinator
- IndustryAI
- Matches133
Built from a search like: “Y Combinator-backed AI companies”
Ranked by current headcount across Y Combinator-backed AI companies. Refreshed daily.
- 1OpenAI· San Francisco, California, United States
- Series unknown
- 7.8k employees
- Founded 2015
- 2BillionToOne· Menlo Park, California, United States
- Series D
- 711 employees
- Founded 2016
- 3Opentrons Labworks Inc.· New York, New York, United States
- Series D
- 201 employees
- Founded 2014
- 454gene· Nigeria
- Convertible note
- 116 employees
- Founded 2019
- 5Nomic Bio· Montreal, Quebec, Canada
- Series B
- 102 employees
- Founded 2017
- 6Culture Biosciences· South San Francisco, California, United States
- Series C
- 79 employees
- Founded 2016
- 7Ansa Biotechnologies, Inc.· Emeryville, California, United States
- Series B
- 71 employees
- Founded 2018
- 8Reshape Biotech· Copenhagen, Capital Region of Denmark, Denmark
- Seed
- 66 employees
- Founded 2018
- 9Planet A Foods· Krailling, Bavaria, Germany
- Corporate
- 64 employees
- Founded 2021
- 10Ochre Bio· Oxford, England, United Kingdom
- Series A
- 60 employees
- Founded 2019
- 11ZBiotics· San Francisco, California, United States
- Secondary
- 58 employees
- Founded 2016
- 12Miracle· San Francisco, California, United States
- Pre-seed
- 56 employees
- Founded 2022
- 13AOA Dx· Denver, Colorado, United States
- Series A
- 54 employees
- Founded 2020
- 14HistoWiz· Brooklyn, New York, United States
- Series A
- 52 employees
- Founded 2012
- 15Volta Labs, Inc.· Boston, Massachusetts, United States
- Series unknown
- 49 employees
- Founded 2018
- 16WhiteLab Genomics· Labretonie, Nouvelle-Aquitaine, France
- Seed
- 49 employees
- Founded 2019
- 17Zymergen· Emeryville, California, United States
- Grant
- 48 employees
- Founded 2008
- 18Mytos· London, England, United Kingdom
- Series A
- 48 employees
- Founded 2016
- 19Acorn Biolabs· Toronto, Ontario, Canada
- Series A
- 48 employees
- Founded 2017
- 20Invert· San Francisco, California, United States
- Seed
- 47 employees
- Founded 2021
- 21Future Fields· Edmonton, Alberta, Canada
- Grant
- 45 employees
- Founded 2018
- 22Yemaachi Biotech· Accra, Greater Accra Region, Ghana
- Seed
- 44 employees
- Founded 2020
- 23PostEra· Boston, Massachusetts, United States
- Grant
- 43 employees
- Founded 2019
- 241910· Boston, Massachusetts, United States
- Series unknown
- 43 employees
- Founded 2018
- 25Elpha· San Francisco, Minnesota, United States
- Seed
- 43 employees
- Founded 2019
Y Combinator’s AI portfolio
The list above ranks Y Combinator-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 133 matching companies in our index give you a quick read on where Y Combinator has gone deepest in the AI space.
Y Combinator’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives — and they show up in AI talent pools across the next decade.
Refolk converts this list into a live search. Ask for “Y Combinator AIcompanies hiring senior engineers” or “founders of Y Combinator-backed AIcompanies” and Refolk returns a fresh ranked shortlist.
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Last refreshed: Thu, 07 May 2026 06:46:53 GMT
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