Lightspeed Venture Partners portfolio AI companies

Multi-stage venture firm with deep practices in enterprise, consumer, and fintech. Filtered to companies in AI.

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Ranked by current headcount across Lightspeed Venture Partners-backed AI companies. Refreshed daily.

1
Natera· Austin, Texas, United States
NateraTM is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera’s tests are supported by more than 325 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California, and through Foresight Diagnostics, its subsidiary, operates an ISO 27001-certified and CAP-accredited laboratory certified under CLIA in Boulder, Colorado. Please be advised that Natera will only reach out to candidates with an @natera.com email domain. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.https://www.natera.com/privacy/
- Post-IPO equity
- 5.9k employees
- Founded 2004
2
Anthropic
We're an AI research company that builds reliable, interpretable, and steerable AI systems. Our first product is Claude, an AI assistant for tasks at any scale.Our research interests span multiple areas including natural language, human feedback, scaling laws, reinforcement learning, code generation, and interpretability.
- Series H
- 5.3k employees
- Founded 2021
3
Guardant Health· Palo Alto, California, United States
Guardant Health is a leading precision medicine company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, we're transforming patient care by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant® tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.Important Note for Job Applicants:Guardant Health is aware of recruiting scams where unauthorized individuals use the company's name in fraudulent emails, job postings, and social media messages. Please note that Guardant Health will never ask for money or credit card information during the job application process, nor does the company communicate with candidates via online chatrooms or personal email accounts such as Gmail or Hotmail.
- Post-IPO debt
- 4.7k employees
- Founded 2012
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4
Snorkel AI· Redwood City, California, United States
Snorkel AI is the frontier AI data lab, helping teams build the data and environments behind high-performing frontier and agentic AI. We combine platform technology with research-driven data development to create datasets, benchmarks, evals, and custom solutions for real-world AI systems. Founded out of the Stanford AI Lab in 2019, Snorkel works with leading AI labs and enterprises to move from better data to better outcomes. Snorkel led the development of Senior SWE-Bench and launched Open Benchmarks Grants with a $3 million commitment to support open-source datasets, benchmarks, and evaluation research. Supported projects include Agents’ Last Exam, OSWorld 2.0, Terminal-Bench, Continual Learning Bench, and SlopCode Bench. Learn more at snorkel.ai or follow @SnorkelAI.
- Series unknown
- 1.3k employees
- Founded 2019
5
ElevenLabs· London, England, United Kingdom
ElevenLabs is transforming human-technology interaction with AI research and products.ElevenAgents enables businesses to deliver seamless and intelligent customer experiences, with the integrations, testing, monitoring, and reliability necessary to deploy voice and chat agents at scale.ElevenCreative empowers creators and marketers to generate and edit speech, music, image, and video across 70+ languages.ElevenAPI gives developers access to our leading AI audio foundational models.These platforms are powered by our leading AI research. We developed the first human-like AI voice model, then expanded into dubbing, transcription, music, sound effects, and speech-to-speech.We serve millions of users and thousands of businesses from the fastest growing startups to the largest enterprises like Harvey, Deutsche Telekom and Meta.
- Secondary
- 1.2k employees
- Founded 2022

6
Neuralink· Austin, Texas, United States
Neuralink is a neurotechnology company building a generalized input/output platform for the brain. Our work has the potential to restore autonomy to those with unmet medical needs and fundamentally transform how humans interact with the world.Our core technology is an implantable brain-computer interface with ultra-thin, flexible electrode threads placed precisely by a surgical robot, enabling high-bandwidth, bidirectional interaction with neural signals.We’ve received multiple FDA Breakthrough Device designations and are conducting clinical trials around the world. Trial participants are exploring how our implant could enhance their daily lives — controlling digital devices like computers and smartphones, operating physical devices like robotic arms and wheelchairs, and translating thought directly into speech and text.Developing brain-computer interfaces is an interdisciplinary challenge, and we’re looking for exceptional talent across engineering, science, and operations. Explore opportunities to contribute to our mission at neuralink.com/careers.
- Series unknown
- 708 employees
- Founded 2016
7
Personalis, Inc.· Fremont, California, United States
At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.
- Post-IPO equity
- 406 employees
- Founded 2011
8
Ultima Genomics· Fremont, California, United States
Ultima Genomics is unleashing the power of genomics at scale. Our mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology’s complexity and dynamic change—and a further need to challenge conventional next-generation sequencing technologies. Ultima’s revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth, and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information and catalyze the next phase of genomics in the 21st century.
- Series unknown
- 309 employees
- Founded 2016
9
Xaira Therapeutics· South San Francisco, California, United States
Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease. We seek to rethink the drug discovery and development process from end-to-end by bringing together leading talent across three core areas: machine learning research to better understand biology, expansive data generation to power new models, and robust therapeutic product development to treat disease. Xaira is headquartered in the San Francisco Bay Area.Please be advised that we will never ask for personal information or any financial commitment from a candidate as a pre-employment requirement. All legitimate Xaira communication regarding our recruitment processes comes from email addresses ending with @xaira.com or through recognized professional networks, such as LinkedIn. To avoid any potential fraudulent activity, please make sure to apply only through Xaira's official Careers page: https://www.xaira.com/work-with-us
- Series A
- 214 employees
- Founded 2023
10
Karius· Redwood City, California, United States
Karius sees a world where infectious disease is no longer a major threat to human health. We are a clinical metagenomics company focused on elevating patient care through microbial insights. By leveraging the power of clinical metagenomics, our vision is to create a world where every patient gets a clear and timely diagnosis.
- Series C
- 213 employees
- Founded 2014

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Lightspeed Venture Partners’s AI portfolio

The list above ranks Lightspeed Venture Partners-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 32 matching companies in Refolk’s index give you a quick read on where Lightspeed Venture Partners has gone deepest in the AI space.

Lightspeed Venture Partners’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives - and they show up in AI talent pools across the next decade.

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How this list is built

Refolk pulled AI companies whose disclosed Crunchbase investor list includes Lightspeed Venture Partners, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 16:01:57 GMT

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