Andreessen Horowitz portfolio AI companies

Multi-stage venture firm investing across consumer, enterprise, fintech, and crypto. Filtered to companies in AI.

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Ranked by current headcount across Andreessen Horowitz-backed AI companies. Refreshed daily.

1
OpenAI· San Francisco, California, United States
OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.
- Series unknown
- 10.5k employees
- Founded 2015
2
Flatiron Health· New York, New York, United States
Flatiron Health’s mission is to improve and extend lives by learning from the experience of every person with cancer.
- Series D
- 1.5k employees
- Founded 2012
3
ElevenLabs· London, England, United Kingdom
ElevenLabs is transforming human-technology interaction with AI research and products.ElevenAgents enables businesses to deliver seamless and intelligent customer experiences, with the integrations, testing, monitoring, and reliability necessary to deploy voice and chat agents at scale.ElevenCreative empowers creators and marketers to generate and edit speech, music, image, and video across 70+ languages.ElevenAPI gives developers access to our leading AI audio foundational models.These platforms are powered by our leading AI research. We developed the first human-like AI voice model, then expanded into dubbing, transcription, music, sound effects, and speech-to-speech.We serve millions of users and thousands of businesses from the fastest growing startups to the largest enterprises like Harvey, Deutsche Telekom and Meta.
- Secondary
- 1.2k employees
- Founded 2022
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4
Freenome· Brisbane, California, United States
Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas. We have raised more than $1.1 billion from leading investors like Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis and the American Cancer Society’s BrightEdge Ventures. A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients' lives, who thrives in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career.
- Post-IPO equity
- 408 employees
- Founded 2014
5
Ultima Genomics· Fremont, California, United States
Ultima Genomics is unleashing the power of genomics at scale. Our mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology’s complexity and dynamic change—and a further need to challenge conventional next-generation sequencing technologies. Ultima’s revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth, and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information and catalyze the next phase of genomics in the 21st century.
- Series unknown
- 309 employees
- Founded 2016

6
insitro· South San Francisco, California, United States
insitro is the physical AI company unlocking causal human biology, founded and led by AI pioneer Daphne Koller. By generating the world’s largest integrated multi-modal corpus of human and cellular data, we’ve built the Virtual HumanTM – a genetically anchored causal AI engine that reveals how disease begins, progresses, and can be resolved. Our platform enables us to precisely identify causal genetic drivers and deploy our TherMLTM AI platform to design optimal medicines, advancing a broad pipeline of therapeutics for neuroscience and metabolic diseases. This industrialized architecture creates a self-learning loop: with every biology we onboard, our predictive models grow smarter, accelerating discovery across scales of biology.Join us in transforming the future of medicine!
- Series C
- 256 employees
- Founded 2018
7
Formation Bio· New York, New York, United States
Formation Bio is an AI-native pharma company differentiated by radically more efficient drug development. The company has built proprietary technology platforms to optimize critical aspects of clinical drug development, enabling more efficient trial design, faster trial completion, and higher quality trial data. Formation Bio acquires clinical-stage drugs from pharmaceutical and biotech companies with the goal to develop assets faster, unlock greater value per program and ultimately accelerate access to new treatments for patients.2025 CNBC Disruptor 502025 Fierce 15 Award2024 Endpoints 11 Award
- Series D
- 197 employees
- Founded 2013
8
Genesis Molecular AI· Burlingame, California, United States
Genesis Molecular AI – headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego and offices in New York – is pioneering foundation models for molecular AI to unlock a new era of drug design and development. We are using a proprietary state-of-the-art generative and predictive AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery.The GEMS platform integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. GEMS accelerates hit ID through lead optimization and candidate selection by generating promising molecules for synthesis and experimental testing, and iterating this process through cycles of AI-enabled discovery and optimization.We have leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has signed AI platform collaborations across a range of therapeutic areas including Gilead (2024), and Incyte (2025).Genesis has raised over $300M in funding from top AI, technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. To learn more about Genesis Molecular AI, or current employment opportunities, please visit our website.
- Corporate
- 172 employees
- Founded 2019
9
Apeel Sciences· Goleta, California, United States
Apeel's evolving technology stack is built on an unprecedented understanding of produce quality and shelf life. This has only deepened as the use of data and technology have given partners a powerful way to accurately and efficiently evaluate produce for ripeness, freshness, and other attributes. Apeel is developing science-backed, technology-supported solutions that help improve the produce experience on shelf.
- Series unknown
- 162 employees
- Founded 2012
10
Nautilus Biotechnology· San Carlos, California, United States
Born from the founders’ recognition that their diverse but complementary skills and experiences would enable them to successfully address challenges that others had not, Nautilus (Nasdaq: NAUT) set about solving a vexing problem: how to bring true proteomics to the world in a way that accelerates therapeutic development, dramatically improves medical diagnostics, and makes personalized and predictive medicine a reality.The extraordinary team at Nautilus represents a wide spectrum of disciplines and expertise, including: protein chemists, chip designers, molecular biologists, data scientists, material scientists, biophysicists, optical engineers, microfluidics engineers, bioinformaticists, software engineers, and more.Nautilus is positioned to revolutionize proteomics, transform the way drugs are developed, and significantly improve the way human health is managed.
- Grant
- 150 employees
- Founded 2016

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Andreessen Horowitz’s AI portfolio

The list above ranks Andreessen Horowitz-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 46 matching companies in Refolk’s index give you a quick read on where Andreessen Horowitz has gone deepest in the AI space.

Andreessen Horowitz’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives - and they show up in AI talent pools across the next decade.

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How this list is built

Refolk pulled AI companies whose disclosed Crunchbase investor list includes Andreessen Horowitz, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes once a day.

Last refreshed: Thu, 06 Aug 2026 02:12:29 GMT

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