Refolk

Seed AI companies in San Francisco

Companies building AI products, foundation models, and applied ML platforms. Filtered to Seed-stage companies headquartered in San Francisco.

Built from a search like: Top Seed AI companies in San Francisco

Ranked by current headcount across Seed AI companies in San Francisco. Refreshed daily.

  1. 1
    Liquid Trees· San Francisco, California, United States
    • Seed
    • 1.6k employees
    • Founded 2022
  2. 2
    OPTIC· San Francisco, California, United States
    • Seed
    • 265 employees
    • Founded 2021
  3. 3
    Athena Alliance· San Francisco, California, United States
    • Seed
    • 248 employees
    • Founded 2021
  4. 4
    Grand Time Research (Coordination Layer)· San Francisco, California, United States
    • Seed
    • 61 employees
    • Founded 2017
  5. 5
    Orchid· San Francisco, California, United States
    • Seed
    • 56 employees
    • Founded 2020
  6. 6
    Invert· San Francisco, California, United States
    • Seed
    • 47 employees
    • Founded 2021
  7. 7
    Elpha· San Francisco, Minnesota, United States
    • Seed
    • 43 employees
    • Founded 2019
  8. 8
    Vivodyne· San Francisco Bay Area
    • Seed
    • 39 employees
    • Founded 2020
  9. 9
    Essential AI· San Francisco, California, United States
    • Seed
    • 37 employees
    • Founded 2023
  10. 10
    Trial Library· San Francisco, California, United States
    • Seed
    • 36 employees
    • Founded 2022
  11. 11
    Not Diamond· San Francisco, California, United States
    • Seed
    • 34 employees
    • Founded 2024
  12. 12
    Rime· San Francisco, California, United States
    • Seed
    • 32 employees
    • Founded 2021
  13. 13
    GOZEN· San Francisco, California, United States
    • Seed
    • 29 employees
    • Founded 2022
  14. 14
    CellCo - The Cell Company· San Francisco, California, United States
    • Seed
    • 28 employees
    • Founded 2024
  15. 15
    Generation Lab· San Francisco, California, United States
    • Seed
    • 26 employees
    • Founded 2023
  16. 16
    Menten AI· San Francisco, California, United States
    • Seed
    • 18 employees
    • Founded 2020
  17. 17
    Valinor· San Francisco, California, United States
    • Seed
    • 18 employees
  18. 18
    Letta· San Francisco, California, United States
    • Seed
    • 17 employees
    • Founded 2024
  19. 19
    ImmuneBridge· San Francisco, California, United States
    • Seed
    • 16 employees
    • Founded 2018
  20. 20
    Shennon Biotechnologies· San Francisco, California, United States
    • Seed
    • 16 employees
    • Founded 2021
  21. 21
    Guide Labs· San Francisco, California, United States
    • Seed
    • 16 employees
    • Founded 2023
  22. 22
    Algen Biotechnologies· San Francisco, California, United States
    • Seed
    • 16 employees
    • Founded 2018
  23. 23
    Eira Bio· San Francisco Bay Area
    • Seed
    • 16 employees
    • Founded 2024
  24. 24
    Node Labs Inc· San Francisco, California, United States
    • Seed
    • 15 employees
    • Founded 2018
  25. 25
    Alljoined· San Francisco, California, United States
    • Seed
    • 15 employees
    • Founded 2023

Find engineers at Seed AI companies in San Francisco

Searching for “engineers at top Seed AI companies in San Francisco” surfaces this slice of the market. The list above ranks AI companies headquartered in San Francisco whose latest disclosed round is Seed, by current headcount, drawn from public LinkedIn and Crunchbase records. With 69 matching companies in our index, this is a tight read on where the AI talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three — Seed, AI, in San Francisco — are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become AI’s next operators and angel investors.

Refolk converts this list into a live search. Ask for “senior engineers at Seed AI companies in San Francisco hiring” or “founders of Seed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist with the evidence behind each match.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose latest disclosed funding round is Seed from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 04:59:28 GMT

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