Refolk

Seed AI companies in San Francisco

Companies building AI products, foundation models, and applied ML platforms. Filtered to Seed-stage companies headquartered in San Francisco.

Edit the query above, or pick a refinement. 500 free credits on sign-up, no card needed.

Built from a search like: Top Seed AI companies in San Francisco

Ranked by current headcount across Seed AI companies in San Francisco. Refreshed monthly.

  1. 1
    OPTIC· San Francisco, California, United States

    AI-powered drug discovery platform for rapid molecule screening and testing, from target identification to lab validation. Automating biotech R&D.About Optic Optic started as an AI research team developing high-performance similarity search algorithms. Today our proprietary AI-technology is powering products in multiple industries from blockchain to biotech.

    • Seed
    • 292 employees
    • Founded 2021
  2. 2
    Athena Alliance· San Francisco, California, United States

    At Athena, we believe career care is self care. Not an indulgence, but an investment. The old model of career growth was linear — climb the ladder, one role at a time, until you reach the top or run out of rungs.Athena exists for the women who are done with that model — who are building something more expansive instead: a portfolio of leadership positions, board seats, advisory roles, ventures, speaking opportunities, and more that reflects the full range of what they have to offer.Expert guidance, real-time education, peer community, and smart connections come together so members can care for their careers continuously — not as a one-time fix, but as a lifelong practice. Because career care is self-care: not something you do once and check off, but something you deliberately tend to over time. And you don’t have to do it alone. Since its founding, Athena has: • Built and nurtured a network of 3,000+ C-level women, VCs, and CEOs from across the full range of industries. • Made thousands of connections between female executives and investment firms, CEOs, and boards. • Supported over 600 women to corporate board roles across the range of public, PE backed, VC backed, ESOPs and more. • Produced hundreds of hours of business leadership content on the most pressing topics - from governing to investing to building. • Offered over 250 virtual events and 100 live in-person events annually across the US. • Launched Athena Academy courses with world-class facultyYour career doesn't build itself. Invest in it with Athena.

    • Seed
    • 236 employees
    • Founded 2021
  3. 3
    Plasmidsaurus· South San Francisco, California, United States

    We sequence whole plasmids, transcriptomes, amplicons, whole genomes, AAV, microbiomes, and colonies overnight, without the need for primers and minipreps.Plasmidsaurus is on a mission to accelerate new cures and promote a healthier planet by unlocking new levels of productivity for scientists. The company's sequencing services are used daily by thousands of innovators, including Nobel Prize winners, dynamic biotech startups, pharmaceutical companies, research labs, and DIY biohackers and have been cited in more than 2500 publications to date. Plasmidsaurus's global network of labs operates day and night to enable world-changing discoveries.Start sequencing: plasmidsaurus.com

    • Seed
    • 148 employees
  4. Live search

    This list is a starting point

    I can run a natural-language search across LinkedIn, GitHub, and the open web. Fire one of these, or edit the box up top to match exactly who you're after.

    500 free credits on sign-up, no card needed.

  5. 4
    Miracle· San Francisco, California, United States

    Pulling your hair out in clinical trials because of spreadsheet madness?You’re not alone. Most biotech teams lose weeks, if not months, to manual spreadsheet trackers, delayed insights, and inadequate vendor oversight.That’s exactly why we built Miracle.👉 Speed: Replace clunky manual trackers with an integrated platform that gets you live in just days (not weeks or months).👉 Clarity: Real-time visibility across trials, so your execs stop asking you for “one quick update” every day.👉 Proof: Clinical-stage biotechs using Miracle have already finished 3-4 months ahead of trial timelines, freeing their teams from spreadsheet hell and resolving risks as soon as they occur, not next week.If you’re a biotech exec staring down another delayed trial (or want to start your study on the right foot), Miracle can help you close the gap.📩 Message us here or reach out at https://www.miracleml.com/contactLet’s make “trial delays” something you don’t talk about next quarter.

    • Seed
    • 75 employees
    • Founded 2022
  6. 5
    Orchid· San Francisco, California, United States

    For the first time, parents have a new superpower. With Orchid, they can safely and naturally mitigate genetic risks in their future child. Sign up to get access at www.orchidhealth.com

    • Seed
    • 65 employees
    • Founded 2020

Find engineers at Seed AI companies in San Francisco

Searching for “engineers at top Seed AI companies in San Francisco” surfaces this slice of the market. The list above ranks AI companies headquartered in San Francisco whose latest disclosed round is Seed, by current headcount, drawn from public LinkedIn and Crunchbase records. With 82 matching companies in Refolk’s index, this is a tight read on where the AI talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Seed, AI, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become AI’s next operators and angel investors.

Refolk converts this list into a live search. Ask for “senior engineers at Seed AI companies in San Francisco hiring” or “founders of Seed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist with the evidence behind each match.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose latest disclosed funding round is Seed from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Sun, 13 Sep 2026 19:02:59 GMT

Search this list

Need an even more specific search?

Refolk runs natural-language searches across LinkedIn, GitHub, and the open web. Try one of these:

500 free credits on sign-up, no card needed.

Related lists

See all company lists.

Slice this list a different way

Common questions

How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

How fresh is the data?

The underlying index updates continuously and this ranking is rebuilt monthly. Last refreshed: Sun, 13 Sep 2026 19:02:59 GMT. For a list built against the index as it stands today, sign up and run the search live.

Can I get the full list of 82 companies?

Yes. This page shows the top of the ranking; sign up and I'll run the search live for the complete, current list. You start with 500 free credits, no card required.

Can I find the people inside these companies?

Yes. Ask in plain English - for example "engineering leaders at these companies who joined in the last year" - and I return the specific people, with context on each.

Try it on the search you came here for

Stop building boolean strings. Just describe the person.

Type one sentence. I plan the search, read GitHub, public LinkedIn and Crunchbase records, and the open web as it is right now, and hand back a ranked list with the reason next to every name.

  1. 01Describe them

    One plain sentence. Role, city, stack, stage, whatever matters to you.

  2. 02I read the web live

    GitHub, public LinkedIn and Crunchbase records, the open web. Not a database that went stale last quarter.

  3. 03You read the shortlist

    Ranked, with the reasoning under every name. Open a profile, ask a follow-up, narrow it down.

  • No boolean, no filters, no seat to buy. One box.
  • Read at search time, so a profile updated yesterday counts today.
  • Every step visible as it runs, every name with its reason.

500 free credits on sign-up. No card, no demo call. See real searches.

Keep exploring