Seed AI companies in San Francisco
Companies building AI products, foundation models, and applied ML platforms. Filtered to Seed-stage companies headquartered in San Francisco.
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- StageSeed
- IndustryAI
- HQSan Francisco
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Built from a search like: “Top Seed AI companies in San Francisco”
Ranked by current headcount across Seed AI companies in San Francisco. Refreshed monthly.
- 1Liquid Trees· San Francisco, California, United States
Say hello to Diatoms.Microscopic plants called Diatoms absorb 10-20 billion tonnes of carbon dioxide (CO2) every year. That's equal to the amount of carbon captured annually by all of the world's rainforests.Diatoms are considered the largest primary producers of oxygen on our planet. It is estimated that through photosynthesis, diatoms produce between 20% and 40% of the oxygen we breathe.With the campaign "Keeping the Planet cool with Diatoms" we are trying to raise awareness about Diatom potential in CO2 removal.We are in the process of removing 10GtCO2 by accelerating the growth of native diatoms in polluted open water systems.
- Seed
- 1.3k employees
- Founded 2022
- 2Calico Life Sciences· South San Francisco, California, United States
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline together create an inspiring and exciting place to catalyze and enable medical breakthroughs.Calico is currently seeking exceptional candidates who share our passion for understanding the science of aging and developing therapeutics to address age-related diseases.Explore with us! https://www.calicolabs.com/careers
- Seed
- 498 employees
- Founded 2013
- 3BIOPTIC· San Francisco, California, United States
AI-powered drug discovery platform for rapid molecule screening and testing, from target identification to lab validation. Automating biotech R&D.About Optic Optic started as an AI research team developing high-performance similarity search algorithms. Today our proprietary AI-technology is powering products in multiple industries from blockchain to biotech.
- Seed
- 292 employees
- Founded 2021
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- 4Athena Alliance· San Francisco, California, United States
At Athena, we believe career care is self care. Not an indulgence, but an investment. The old model of career growth was linear — climb the ladder, one role at a time, until you reach the top or run out of rungs.Athena exists for the women who are done with that model — who are building something more expansive instead: a portfolio of leadership positions, board seats, advisory roles, ventures, speaking opportunities, and more that reflects the full range of what they have to offer.Expert guidance, real-time education, peer community, and smart connections come together so members can care for their careers continuously — not as a one-time fix, but as a lifelong practice. Because career care is self-care: not something you do once and check off, but something you deliberately tend to over time. And you don’t have to do it alone. Since its founding, Athena has: • Built and nurtured a network of 3,000+ C-level women, VCs, and CEOs from across the full range of industries. • Made thousands of connections between female executives and investment firms, CEOs, and boards. • Supported over 600 women to corporate board roles across the range of public, PE backed, VC backed, ESOPs and more. • Produced hundreds of hours of business leadership content on the most pressing topics - from governing to investing to building. • Offered over 250 virtual events and 100 live in-person events annually across the US. • Launched Athena Academy courses with world-class facultyYour career doesn't build itself. Invest in it with Athena.
- Seed
- 236 employees
- Founded 2021
- 5Plasmidsaurus· South San Francisco, California, United States
We sequence whole plasmids, transcriptomes, amplicons, whole genomes, AAV, microbiomes, and colonies overnight, without the need for primers and minipreps.Plasmidsaurus is on a mission to accelerate new cures and promote a healthier planet by unlocking new levels of productivity for scientists. The company's sequencing services are used daily by thousands of innovators, including Nobel Prize winners, dynamic biotech startups, pharmaceutical companies, research labs, and DIY biohackers and have been cited in more than 2500 publications to date. Plasmidsaurus's global network of labs operates day and night to enable world-changing discoveries.Start sequencing: plasmidsaurus.com
- Seed
- 148 employees
Find engineers at Seed AI companies in San Francisco
Searching for “engineers at top Seed AI companies in San Francisco” surfaces this slice of the market. The list above ranks AI companies headquartered in San Francisco whose latest disclosed round is Seed, by current headcount, drawn from public LinkedIn and Crunchbase records. With 90 matching companies in Refolk’s index, this is a tight read on where the AI talent in San Francisco is heating up.
Three filters at once narrows the field hard. The companies that survive all three - Seed, AI, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become AI’s next operators and angel investors.
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Last refreshed: Tue, 13 Oct 2026 20:52:49 GMT
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Related lists
- Seed SaaS in San Francisco
- Seed Fintech in San Francisco
- Seed Developer tools in San Francisco
- Seed Cybersecurity in San Francisco
- Series A AI in San Francisco
- Series A SaaS in San Francisco
- Series A Fintech in San Francisco
- Series A Developer tools in San Francisco
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The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.
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