Top AI companies in San Francisco

Companies building AI products, foundation models, and applied ML platforms. Filtered to companies headquartered in San Francisco.

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Ranked by current headcount across AI companies headquartered in San Francisco. Refreshed daily.

1
Genentech· South San Francisco, California, United States
About GenentechWe're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal.Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683)Monday-Friday, 6am-5pm PST or patientinfo@gene.com. Community Guidelines:1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages.2. Don’t mention any medicines by name — ours or anyone else’s.Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments.3. This isn’t the place to report or discuss side effects.This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.4. Don’t pitch your product or service.Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
- Series A
- 18.3k employees
- Founded 1976
2
OpenAI· San Francisco, California, United States
OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.
- Series unknown
- 10.5k employees
- Founded 2015
3
Liquid Trees· San Francisco, California, United States
Say hello to Diatoms.Microscopic plants called Diatoms absorb 10-20 billion tonnes of carbon dioxide (CO2) every year. That's equal to the amount of carbon captured annually by all of the world's rainforests.Diatoms are considered the largest primary producers of oxygen on our planet. It is estimated that through photosynthesis, diatoms produce between 20% and 40% of the oxygen we breathe.With the campaign "Keeping the Planet cool with Diatoms" we are trying to raise awareness about Diatom potential in CO2 removal.We are in the process of removing 10GtCO2 by accelerating the growth of native diatoms in polluted open water systems.
- Seed
- 1.4k employees
- Founded 2022
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4
Twist Bioscience· South San Francisco, California, United States
Twist Bioscience is a synthetic biology company based in South San Francisco, California. The company has developed a proprietary silicon-based manufacturing process for the production of synthetic DNA. Twist Bioscience serves Life Science researchers who are changing the world for the better. Coming from diverse fields of medicine, agriculture, and industrial chemicals, scientists use our synthetic genes, oligo pools, biopharma services, and NGS target enrichment to better lives and improve the sustainability of the planet. Twist Bioscience is uniquely positioned to help accelerate these efforts by providing precision at a scale that is otherwise unavailable. Our technology overcomes inefficiencies and enables cost-effective, rapid, precise, high-throughput DNA synthesis and sequencing. We offer both the quality and quantity researchers need now to rapidly realize opportunities ahead. X @TwistBioscienceInstagram @twist_bioscienceYouTube youtube.com/TwistBioscience#WeMakeDNA
- Post-IPO equity
- 1.3k employees
- Founded 2013
5
WestEd· San Francisco, California, United States
WestEd, a national nonpartisan, nonprofit research, development, and service agency, operates with a clear vision to support thriving learners and empowered communities. We apply unrivaled expertise to significant questions and important issues related to learning, working across education, health, justice, policy, labor, child welfare, and other disciplines to create positive results for clients and communities. We hire and partner with curious, insightful people with a passion for learning. More than half of our staff hold advanced degrees. Our culture is professional, responsible, and reliable. WestEd has 13 offices nationwide, from Washington and Boston to Arizona and California. Our corporate headquarters are in San Francisco. Learn more about job openings and life at WestEd by visiting WestEd.org/careers. Stay up to date on the latest research and receive timely insights by subscribing to WestEd's E-Bulletin: https://www.wested.org/subscribe/
- Grant
- 1.2k employees
- Founded 1966

6
Cytokinetics· South San Francisco, California, United States
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
- Post-IPO equity
- 792 employees
- Founded 1998
7
Veracyte, Inc.· South San Francisco, California, United States
Veracyte is a global diagnostics company that empowers clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer. Our growing menu of diagnostic tests answers important clinical questions to help patients avoid risky, costly procedures and interventions, and accelerate time to appropriate treatment.
- Post-IPO equity
- 733 employees
- Founded 2008
8
Invitae· San Francisco, California, United States
Invitae, now part of Labcorp, is a leading medical genetics company trusted by millions of patients and their providers to deliver timely genetic information using digital technology. We’re working to provide accurate and actionable answers to strengthen medical decision-making for individuals and their families. Invitae's genetics experts apply a rigorous approach to data and research, serving as the foundation of our mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people.Within each of us lies information coded in our DNA that can transform our health. Unlocking that potential requires highly specialized, multidisciplinary collaboration. Our world-class genetics experts drive the development of a highly complex system of tools and processes, including robotics, artificial intelligence, machine learning, and software engineering. All of this comes together to provide patients with accurate, reliable results that can help guide decisions across the healthcare journey and potentially change lives today and for the next generation.Our teammates are grounded in a universal sense of urgency and ownership. We believe in the team above the individual and celebrate freedom with accountability. Employees are encouraged to speak up, try new things and make decisions that push us forward. We provide all Invitaens with opportunities to grow and advance, supported by flexible work hours, unlimited paid time off, the ability to work anywhere for many roles and the satisfaction of doing meaningful work. At Invitae, we're putting patients' genetic insights where they belong—at the center of healthcare. And we're doing it together, with you.Join us.
- Post-IPO debt
- 674 employees
- Founded 2010
9
Gladstone Institutes· San Francisco, California, United States
Gladstone's mission is to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.Although Gladstone shares traits with other top life science organizations, we pride ourselves on taking uncommon scientific paths to overcoming disease. Our investigators are selected to become authorities in leading or creating new fields, and we work to provide them with resources to explore bold new thoughts, form effective scientific teams, and create or master emerging research technologies that accelerate progress—Gladstone’s special recipe for success that has yielded some of the most important biomedical advances of our time.Our three disease-focused institutes constitute the core of our discovery engine, but do not operate in isolation. We are seizing unprecedented opportunities for “convergence”—defined as the blending of intellectual and physical assets from multiple scientific disciplines and fields to speed the discovery process in our attack on unsolved health problems that affect almost every human family.
- Grant
- 607 employees
- Founded 1979
10
Denali Therapeutics· South San Francisco, California, United States
Denali Therapeutics is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier using our proprietary TransportVehicleTM platform. We discover, develop and deliver medicines for people living with neurodegenerative, lysosomal storage and other serious diseases.
- Post-IPO debt
- 602 employees
- Founded 2015

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Find engineers at AI companies in San Francisco

San Francisco has long been a hub for AI, and the list above ranks the largest AI companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 369 matching companies in Refolk’s index, this is a good map of where the AI talent in San Francisco lives - useful whether you’re recruiting, partnering, or sizing a market.

The biggest AI companies in San Francisco tend to be the gravitational centres for specialised talent - senior engineers, ML researchers, applied scientists, designers - while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “AI engineers in San Francisco hiring senior staff” or “founders of AI companies in San Francisco who left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled AI companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 11:05:38 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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