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Top AI companies in San Francisco

Companies building AI products, foundation models, and applied ML platforms. Filtered to companies headquartered in San Francisco.

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Built from a search like: “Top AI companies in San Francisco”

Ranked by current headcount across AI companies headquartered in San Francisco. Refreshed daily.

  1. 1
    Genentech· South San Francisco, California, United States
    • Series A
    • 18.2k employees
    • Founded 1976
  2. 2
    OpenAI· San Francisco, California, United States
    • Series unknown
    • 9.4k employees
    • Founded 2015
  3. 3
    Liquid Trees· San Francisco, California, United States
    • Seed
    • 1.5k employees
    • Founded 2022
  4. 4
    Twist Bioscience· South San Francisco, California, United States
    • Post-IPO equity
    • 1.3k employees
    • Founded 2013
  5. 5
    WestEd· San Francisco, California, United States
    • Grant
    • 1.2k employees
    • Founded 1966
Reveal 357 more·100 free credits, no card

Find engineers at AI companies in San Francisco

San Francisco has long been a hub for AI, and the list above ranks the largest AI companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 362 matching companies in our index, this is a good map of where the AI talent in San Franciscolives - useful whether you’re recruiting, partnering, or sizing a market.

The biggest AI companies in San Francisco tend to be the gravitational centres for specialised talent - senior engineers, ML researchers, applied scientists, designers - while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “AI engineers in San Franciscohiring senior staff” or “founders of AI companies in San Franciscowho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled AI companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Sun, 21 Jun 2026 09:18:53 GMT

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