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Top Biotech companies in San Francisco

Companies applying biology, chemistry, and computation to therapeutics and tooling. Filtered to companies headquartered in San Francisco.

Built from a search like: “Top Biotech companies in San Francisco”

Ranked by current headcount across Biotech companies headquartered in San Francisco. Refreshed daily.

  1. 1
    Genentech· South San Francisco, California, United States
    • Series A
    • 18.1k employees
    • Founded 1976
  2. 2
    Liquid Trees· San Francisco, California, United States
    • Seed
    • 1.6k employees
    • Founded 2022
  3. 3
    Twist Bioscience· South San Francisco, California, United States
    • Post-IPO equity
    • 1.2k employees
    • Founded 2013
  4. 4
    Cytokinetics· South San Francisco, California, United States
    • Post-IPO debt
    • 729 employees
    • Founded 1998
  5. 5
    Invitae· San Francisco, California, United States
    • Post-IPO debt
    • 703 employees
    • Founded 2010
  6. 6
    Veracyte, Inc.· South San Francisco, California, United States
    • Post-IPO equity
    • 691 employees
    • Founded 2008
  7. 7
    Nektar Therapeutics· San Francisco, California, United States
    • Post-IPO equity
    • 604 employees
    • Founded 1990
  8. 8
    Denali Therapeutics· South San Francisco, California, United States
    • Post-IPO debt
    • 570 employees
    • Founded 2015
  9. 9
    Standard BioTools· South San Francisco, California, United States
    • Post-IPO equity
    • 521 employees
    • Founded 1999
  10. 10
    Vir Biotechnology, Inc.· San Francisco, California, United States
    • Post-IPO equity
    • 479 employees
    • Founded 2016
  11. 11
    Calico Life Sciences· South San Francisco, California, United States
    • 449 employees
    • Founded 2013
  12. 12
    Rigel Pharmaceuticals Inc.· South San Francisco, California, United States
    • Grant
    • 285 employees
    • Founded 1996
  13. 13
    FibroGen, Inc.· San Francisco, California, United States
    • Post-IPO debt
    • 274 employees
    • Founded 1993
  14. 14
    OPTIC· San Francisco, California, United States
    • Seed
    • 265 employees
    • Founded 2021
  15. 15
    insitro· South San Francisco, California, United States
    • Series C
    • 247 employees
    • Founded 2018
  16. 16
    California Institute for Regenerative Medicine (CIRM)· South San Francisco, California, United States
    • 242 employees
    • Founded 2004
  17. 17
    Alumis· South San Francisco, California, United States
    • Post-IPO equity
    • 232 employees
    • Founded 2021
  18. 18
    IDEAYA Biosciences· South San Francisco, California, United States
    • Post-IPO equity
    • 232 employees
    • Founded 2015
  19. 19
    Lyell Immunopharma· South San Francisco, California, United States
    • Post-IPO equity
    • 222 employees
    • Founded 2018
  20. 20
    Sutro Biopharma, Inc.· South San Francisco, California, United States
    • Post-IPO equity
    • 221 employees
    • Founded 2003
  21. 21
    Arsenal Biosciences, Inc.· South San Francisco, California, United States
    • Series C
    • 203 employees
    • Founded 2019
  22. 22
    Allogene Therapeutics· South San Francisco, California, United States
    • Post-IPO equity
    • 203 employees
    • Founded 2017
  23. 23
    Onyx Pharmaceuticals, Inc., an Amgen subsidiary· South San Francisco, California, United States
    • 194 employees
    • Founded 1991
  24. 24
    Xaira Therapeutics· South San Francisco, California, United States
    • Series A
    • 192 employees
    • Founded 2023
  25. 25
    Structure Therapeutics· South San Francisco, California, United States
    • Post-IPO equity
    • 188 employees
    • Founded 2017

Find engineers at Biotech companies in San Francisco

San Francisco has long been a hub for Biotech, and the list above ranks the largest Biotech companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 294 matching companies in our index, this is a good map of where the Biotech talent in San Franciscolives — useful whether you’re recruiting, partnering, or sizing a market.

The biggest Biotech companies in San Francisco tend to be the gravitational centres for specialised talent — senior engineers, ML researchers, applied scientists, designers — while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “Biotech engineers in San Franciscohiring senior staff” or “founders of Biotech companies in San Franciscowho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled Biotech companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 07:28:45 GMT

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