Top Data infrastructure companies in San Francisco
Databases, warehouses, lakes, pipelines, and observability for production data. Filtered to companies headquartered in San Francisco.
- IndustryData infrastructure
- HQSan Francisco
- Matches3,115
Built from a search like: “Top Data infrastructure companies in San Francisco”
Ranked by current headcount across Data infrastructure companies headquartered in San Francisco. Refreshed daily.
- 1Upwork· San Francisco, California, United States
- Series unknown
- 170.5k employees
- Founded 2015
- 2Salesforce· San Francisco, California, United States
- Post-IPO debt
- 87.7k employees
- 3DoorDash· San Francisco, California, United States
- 80k employees
- Founded 2013
- 4Airbnb· San Francisco, California, United States
- Post-IPO debt
- 69.2k employees
- Founded 2007
- 5N/A· San Francisco, California, United States
- 29.8k employees
- Founded 1988
- 6Globant· San Francisco, California, United States
- 28.5k employees
- Founded 2003
- 7Instacart· San Francisco, California, United States
- Private equity
- 24.3k employees
- Founded 2012
- 8Twitch· San Francisco, California, United States
- Series C
- 17.5k employees
- Founded 2011
- 9Autodesk· San Francisco, California, United States
- Post-IPO debt
- 15.6k employees
- Founded 1982
- 10Databricks· San Francisco, California, United States
- Debt
- 14.9k employees
- Founded 2013
- 11Pinterest· San Francisco, California, United States
- Post-IPO debt
- 13.4k employees
- Founded 2010
- 12Railway· San Francisco, California, United States
- Series B
- 10.7k employees
- Founded 2020
- 13Splunk· San Francisco, California, United States
- Post-IPO equity
- 9.5k employees
- Founded 2003
- 14Docusign· San Francisco, California, United States
- Post-IPO debt
- 8.4k employees
- Founded 2003
- 15Rippling· San Francisco, California, United States
- Series G
- 7.2k employees
- Founded 2016
- 16Okta· San Francisco, California, United States
- Post-IPO equity
- 7.2k employees
- Founded 2009
- 17Unity· San Francisco, California, United States
- Post-IPO debt
- 7.1k employees
- Founded 2004
- 18Yelp· San Francisco, California, United States
- 7.1k employees
- Founded 2004
- 19Cloudflare· San Francisco, California, United States
- Post-IPO debt
- 6.9k employees
- Founded 2009
- 20Square· San Francisco, California, United States
- 6.8k employees
- Founded 2009
- 21Zendesk· San Francisco, California, United States
- 6.7k employees
- Founded 2007
- 22HackerOne· San Francisco, California, United States
- Series unknown
- 6.6k employees
- Founded 2012
- 23Twilio· San Francisco, California, United States
- Post-IPO equity
- 6.6k employees
- Founded 2008
- 24Scale AI· San Francisco, California, United States
- Corporate
- 6.5k employees
- Founded 2016
- 25Handshake· San Francisco, California, United States
- Series F
- 6.3k employees
- Founded 2014
Find engineers at Data infrastructure companies in San Francisco
San Francisco has long been a hub for Data infrastructure, and the list above ranks the largest Data infrastructure companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 3,115 matching companies in our index, this is a good map of where the Data infrastructure talent in San Franciscolives — useful whether you’re recruiting, partnering, or sizing a market.
The biggest Data infrastructure companies in San Francisco tend to be the gravitational centres for specialised talent — senior engineers, ML researchers, applied scientists, designers — while the smaller ones compete on speed, equity, and proximity to founders.
Refolk converts this list into a live search. Ask for “Data infrastructure engineers in San Franciscohiring senior staff” or “founders of Data infrastructure companies in San Franciscowho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.
How this list is built
Last refreshed: Thu, 07 May 2026 05:59:13 GMT
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