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Top Data infrastructure companies in San Francisco

Databases, warehouses, lakes, pipelines, and observability for production data. Filtered to companies headquartered in San Francisco.

Built from a search like: Top Data infrastructure companies in San Francisco

Ranked by current headcount across Data infrastructure companies headquartered in San Francisco. Refreshed daily.

  1. 1
    Upwork· San Francisco, California, United States
    • Series unknown
    • 170.5k employees
    • Founded 2015
  2. 2
    Salesforce· San Francisco, California, United States
    • Post-IPO debt
    • 87.7k employees
  3. 3
    DoorDash· San Francisco, California, United States
    • 80k employees
    • Founded 2013
  4. 4
    Airbnb· San Francisco, California, United States
    • Post-IPO debt
    • 69.2k employees
    • Founded 2007
  5. 5
    N/A· San Francisco, California, United States
    • 29.8k employees
    • Founded 1988
  6. 6
    Globant· San Francisco, California, United States
    • 28.5k employees
    • Founded 2003
  7. 7
    Instacart· San Francisco, California, United States
    • Private equity
    • 24.3k employees
    • Founded 2012
  8. 8
    Twitch· San Francisco, California, United States
    • Series C
    • 17.5k employees
    • Founded 2011
  9. 9
    Autodesk· San Francisco, California, United States
    • Post-IPO debt
    • 15.6k employees
    • Founded 1982
  10. 10
    Databricks· San Francisco, California, United States
    • Debt
    • 14.9k employees
    • Founded 2013
  11. 11
    Pinterest· San Francisco, California, United States
    • Post-IPO debt
    • 13.4k employees
    • Founded 2010
  12. 12
    Railway· San Francisco, California, United States
    • Series B
    • 10.7k employees
    • Founded 2020
  13. 13
    Splunk· San Francisco, California, United States
    • Post-IPO equity
    • 9.5k employees
    • Founded 2003
  14. 14
    Docusign· San Francisco, California, United States
    • Post-IPO debt
    • 8.4k employees
    • Founded 2003
  15. 15
    Rippling· San Francisco, California, United States
    • Series G
    • 7.2k employees
    • Founded 2016
  16. 16
    Okta· San Francisco, California, United States
    • Post-IPO equity
    • 7.2k employees
    • Founded 2009
  17. 17
    Unity· San Francisco, California, United States
    • Post-IPO debt
    • 7.1k employees
    • Founded 2004
  18. 18
    Yelp· San Francisco, California, United States
    • 7.1k employees
    • Founded 2004
  19. 19
    Cloudflare· San Francisco, California, United States
    • Post-IPO debt
    • 6.9k employees
    • Founded 2009
  20. 20
    Square· San Francisco, California, United States
    • 6.8k employees
    • Founded 2009
  21. 21
    Zendesk· San Francisco, California, United States
    • 6.7k employees
    • Founded 2007
  22. 22
    HackerOne· San Francisco, California, United States
    • Series unknown
    • 6.6k employees
    • Founded 2012
  23. 23
    Twilio· San Francisco, California, United States
    • Post-IPO equity
    • 6.6k employees
    • Founded 2008
  24. 24
    Scale AI· San Francisco, California, United States
    • Corporate
    • 6.5k employees
    • Founded 2016
  25. 25
    Handshake· San Francisco, California, United States
    • Series F
    • 6.3k employees
    • Founded 2014

Find engineers at Data infrastructure companies in San Francisco

San Francisco has long been a hub for Data infrastructure, and the list above ranks the largest Data infrastructure companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 3,115 matching companies in our index, this is a good map of where the Data infrastructure talent in San Franciscolives — useful whether you’re recruiting, partnering, or sizing a market.

The biggest Data infrastructure companies in San Francisco tend to be the gravitational centres for specialised talent — senior engineers, ML researchers, applied scientists, designers — while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for Data infrastructure engineers in San Franciscohiring senior staff” or “founders of Data infrastructure companies in San Franciscowho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled Data infrastructure companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 05:59:13 GMT

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