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Top Blockchain companies in San Francisco

Companies building L1s, L2s, wallets, infra, and apps on public blockchains. Filtered to companies headquartered in San Francisco.

Built from a search like: “Top Blockchain companies in San Francisco”

Ranked by current headcount across Blockchain companies headquartered in San Francisco. Refreshed daily.

  1. 1
    Wells Fargo· San Francisco, California, United States
    • 210.3k employees
  2. 2
    Union Bank· San Francisco, California, United States
    • 8.2k employees
  3. 3
    SoFi· San Francisco, California, United States
    • Post-IPO equity
    • 6.2k employees
    • Founded 2011
  4. 4
    Delta Dental Ins.· San Francisco, California, United States
    • 6k employees
    • Founded 1955
  5. 5
    Toko· San Francisco, California, United States
    • 3.9k employees
    • Founded 2017
  6. 6
    Andersen· San Francisco, California, United States
    • 3.4k employees
    • Founded 2013
  7. 7
    TPG· San Francisco, California, United States
    • Post-IPO debt
    • 3.1k employees
    • Founded 1992
  8. 8
    Affirm· San Francisco, California, United States
    • Post-IPO debt
    • 3k employees
    • Founded 2012
  9. 9
    Chime· San Francisco, California, United States
    • Debt
    • 2.4k employees
    • Founded 2012
  10. 10
    Federal Reserve Bank of San Francisco· San Francisco, California, United States
    • 1.9k employees
    • Founded 1913
  11. 11
    Brex· San Francisco, California, United States
    • Debt
    • 1.8k employees
    • Founded 2017
  12. 12
    PayJoy· San Francisco, California, United States
    • Debt
    • 1.7k employees
    • Founded 2015
  13. 13
    Go· San Francisco, California, United States
    • Series unknown
    • 1.6k employees
    • Founded 2014
  14. 14
    Upgrade, Inc.· San Francisco, California, United States
    • Debt
    • 1.6k employees
    • Founded 2016
  15. 15
    SS&C Advent· San Francisco, California, United States
    • 1.6k employees
    • Founded 1983
  16. 16
    Mercury· San Francisco, California, United States
    • Series C
    • 1.5k employees
    • Founded 2017
  17. 17
    First Republic· San Francisco, California, United States
    • Post-IPO equity
    • 1.5k employees
    • Founded 1985
  18. 18
    LendingClub· San Francisco, California, United States
    • Post-IPO equity
    • 1.4k employees
    • Founded 2007
  19. 19
    Esurance· San Francisco, California, United States
    • 1.2k employees
    • Founded 1999
  20. 20
    Hustle Fund· San Francisco, California, United States
    • 1.2k employees
    • Founded 2017
  21. 21
    Nium· San Francisco, California, United States
    • Series unknown
    • 1k employees
    • Founded 2016
  22. 22
    Berkshire Hathaway Homestate Companies - Workers Compensation Division· San Francisco, California, United States
    • 979 employees
  23. 23
    Sixth Street· San Francisco, California, United States
    • Private equity
    • 925 employees
    • Founded 2009
  24. 24
    Wells Fargo Private Wealth· San Francisco, California, United States
    • 921 employees
  25. 25
    Standish Management, LLC· San Francisco, California, United States
    • 907 employees
    • Founded 2007

Find engineers at Blockchain companies in San Francisco

San Francisco has long been a hub for Blockchain, and the list above ranks the largest Blockchain companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 1,164 matching companies in our index, this is a good map of where the Blockchain talent in San Franciscolives — useful whether you’re recruiting, partnering, or sizing a market.

The biggest Blockchain companies in San Francisco tend to be the gravitational centres for specialised talent — senior engineers, ML researchers, applied scientists, designers — while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “Blockchain engineers in San Franciscohiring senior staff” or “founders of Blockchain companies in San Franciscowho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled Blockchain companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 07:47:31 GMT

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