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Top Biotech companies in Boston

Companies applying biology, chemistry, and computation to therapeutics and tooling. Filtered to companies headquartered in Boston.

Built from a search like: “Top Biotech companies in Boston”

Ranked by current headcount across Biotech companies headquartered in Boston. Refreshed daily.

  1. 1
    Vertex Pharmaceuticals· Boston, Massachusetts, United States
    • post ipo secondary
    • 6.2k employees
    • Founded 1989
  2. 2
    Alexion Pharmaceuticals, Inc.· New Boston, Massachusetts, United States
    • Post-IPO equity
    • 5.1k employees
    • Founded 1992
  3. 3
    argenx· Boston, Massachusetts, United States
    • Post-IPO equity
    • 2.1k employees
    • Founded 2008
  4. 4
    Foundation Medicine· Boston, Massachusetts, United States
    • Series B
    • 1.8k employees
    • Founded 2010
  5. 5
    Ginkgo Bioworks· Boston, Massachusetts, United States
    • 644 employees
    • Founded 2009
  6. 6
    Velsera· Boston, Massachusetts, United States
    • 436 employees
    • Founded 2023
  7. 7
    Rhythm Pharmaceuticals Inc.· Boston, Massachusetts, United States
    • Post-IPO equity
    • 435 employees
    • Founded 2008
  8. 8
    Nucleate· Boston, Massachusetts, United States
    • 428 employees
    • Founded 2019
  9. 9
    Wyss Institute at Harvard University· Boston, Massachusetts, United States
    • 372 employees
  10. 10
    CRISPR Therapeutics· Boston, Massachusetts, United States
    • Post-IPO debt
    • 366 employees
    • Founded 2013
  11. 11
    Ironwood Pharmaceuticals· Boston, Massachusetts, United States
    • Post-IPO debt
    • 261 employees
    • Founded 1998
  12. 12
    Fortis Life Sciences· Boston, Massachusetts, United States
    • 222 employees
    • Founded 2020
  13. 13
    Monte Rosa Therapeutics· Boston, Massachusetts, United States
    • Post-IPO equity
    • 208 employees
    • Founded 2018
  14. 14
    AVEO Oncology· Boston, Massachusetts, United States
    • Post-IPO equity
    • 201 employees
    • Founded 2001
  15. 15
    Entrada Therapeutics· Boston, Massachusetts, United States
    • Post-IPO equity
    • 199 employees
    • Founded 2016
  16. 16
    Praxis Precision Medicines, Inc.· Boston, Massachusetts, United States
    • Post-IPO equity
    • 192 employees
    • Founded 2015
  17. 17
    Akili· Boston, Massachusetts, United States
    • Series D
    • 175 employees
    • Founded 2015
  18. 18
    Verve Therapeutics· Boston, Massachusetts, United States
    • Post-IPO equity
    • 171 employees
    • Founded 2018
  19. 19
    Manus· Boston, Massachusetts, United States
    • Grant
    • 168 employees
    • Founded 2011
  20. 20
    Tango Therapeutics· Boston, Massachusetts, United States
    • Post-IPO equity
    • 160 employees
    • Founded 2017
  21. 21
    Seven Bridges· Boston, Massachusetts, United States
    • Series C
    • 150 employees
    • Founded 2009
  22. 22
    Solid Biosciences· Boston, Massachusetts, United States
    • Post-IPO equity
    • 147 employees
    • Founded 2013
  23. 23
    Drug Hunter· Boston, Massachusetts, United States
    • Seed
    • 143 employees
    • Founded 2018
  24. 24
    enGene· Boston, Massachusetts, United States
    • Post-IPO debt
    • 139 employees
    • Founded 1999
  25. 25
    ODC Life Sciences· Boston, Massachusetts, United States
    • 132 employees
    • Founded 2017

Find engineers at Biotech companies in Boston

Boston has long been a hub for Biotech, and the list above ranks the largest Biotech companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 215 matching companies in our index, this is a good map of where the Biotech talent in Bostonlives — useful whether you’re recruiting, partnering, or sizing a market.

The biggest Biotech companies in Boston tend to be the gravitational centres for specialised talent — senior engineers, ML researchers, applied scientists, designers — while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “Biotech engineers in Bostonhiring senior staff” or “founders of Biotech companies in Bostonwho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled Biotech companies headquartered in Boston from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 03:39:28 GMT

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