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Khosla Ventures portfolio AI companies

Vinod Khosla's firm - deeptech, climate, healthcare, and contrarian software bets. Filtered to companies in AI.

Built from a search like: Khosla Ventures-backed AI companies

Ranked by current headcount across Khosla Ventures-backed AI companies. Refreshed daily.

  1. 1
    OpenAI· San Francisco, California, United States

    OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

    • Series unknown
    • 10.5k employees
    • Founded 2015
  2. 2
    Guardant Health· Palo Alto, California, United States

    Guardant Health is a leading precision medicine company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, we're transforming patient care by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant® tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.Important Note for Job Applicants:Guardant Health is aware of recruiting scams where unauthorized individuals use the company's name in fraudulent emails, job postings, and social media messages. Please note that Guardant Health will never ask for money or credit card information during the job application process, nor does the company communicate with candidates via online chatrooms or personal email accounts such as Gmail or Hotmail.

    • Post-IPO debt
    • 4.7k employees
    • Founded 2012
  3. 3
    Amyris· Emeryville, California, United States

    Amyris is a vertically integrated biomanufacturing company that creates specialty molecules for a range of industries, including flavors and fragrances, advanced materials, beauty and personal care, food, and more. Using advanced fermentation technology, Amyris customizes, creates, and manufactures ingredients that enhance lives, protect ecosystems, and take products to the next level of performance.Amyris was founded in 2003 with a bold humanitarian vision to transform access to a lifesaving antimalarial compound using biotechnology. Now, with over two decades of proven commercial success, our proprietary platform is redefining the precision, consistency, and sustainability that is possible with renewable biological chemistry.

    • Grant
    • 991 employees
    • Founded 2003
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  5. 4
    Ultima Genomics· Fremont, California, United States

    Ultima Genomics is unleashing the power of genomics at scale. Our mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology’s complexity and dynamic change—and a further need to challenge conventional next-generation sequencing technologies. Ultima’s revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth, and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information and catalyze the next phase of genomics in the 21st century.

    • Series unknown
    • 309 employees
    • Founded 2016
  6. 5
    Karius· Redwood City, California, United States

    Karius sees a world where infectious disease is no longer a major threat to human health. We are a clinical metagenomics company focused on elevating patient care through microbial insights. By leveraging the power of clinical metagenomics, our vision is to create a world where every patient gets a clear and timely diagnosis.

    • Series C
    • 213 employees
    • Founded 2014

Khosla Ventures’s AI portfolio

The list above ranks Khosla Ventures-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 55 matching companies in Refolk’s index give you a quick read on where Khosla Ventures has gone deepest in the AI space.

Khosla Ventures’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives - and they show up in AI talent pools across the next decade.

Refolk converts this list into a live search. Ask for Khosla Ventures AI companies hiring senior engineers” or “founders of Khosla Ventures-backed AI companies” and Refolk returns a fresh ranked shortlist.

How this list is built

Refolk pulled AI companies whose disclosed Crunchbase investor list includes Khosla Ventures, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 16:02:51 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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