Andreessen Horowitz AI portfolio in San Francisco

Multi-stage venture firm investing across consumer, enterprise, fintech, and crypto. Filtered to AI companies headquartered in San Francisco.

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Ranked by current headcount across Andreessen Horowitz-backed AI companies in San Francisco. Refreshed monthly.

1
OpenAI· San Francisco, California, United States
OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.
- Series unknown
- 10.5k employees
- Founded 2015
2
Arena· San Francisco, California, United States
Created by researchers from UC Berkeley, Arena (formerly LMArena) is a community-powered platform to measure and advance the frontier of AI for real-world use. Tens of millions of builders, researchers, and creative professionals come to Arena to use frontier models and give feedback on their responses, shaping a public leaderboard grounded in real-world use.
- Series A
- 82 employees
- Founded 2025
3
Cartography Biosciences· South San Francisco, California, United States
Building a smarter roadmap for precision therapeutics.
- Series unknown
- 69 employees
- Founded 2020
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4
Rezo Therapeutics· San Francisco, California, United States
Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it. Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs.
- Series A
- 45 employees
- Founded 2021
5
Arda Therapeutics· San Francisco Bay Area
Arda is taking aim at chronic diseases and aging by eliminating the pathogenic cells that drive these conditions.
- Series A
- 21 employees
- Founded 2021

6
Phylo· South San Francisco, California, United States
Phylo is an applied research lab dedicated to studying agentic intelligence to accelerate discoveries for every biomedical scientist. Building Biomni Lab - the first integrated biology environment.
- Seed
- 15 employees
7
QuiverAI· San Francisco, California, United States
An AI research and product company building world-class models and tools for vector generation and editing.
- Seed
- 15 employees
- Founded 2025
8
Kits.AI· San Francisco, California, United States
Kits.AI is an AI Audio research company building music tools for the next generation of creators.Our research focuses on AI Singing + Music architectures and is committed to licensed data sourcing practices.We combine leading AI Music research with deep music production experience to deploy music tools that fit seamlessly into musician workflows. Kits.AI tools have been used by over 6,000,000 creators to access infinite singing voices for production, clone and share their own voice to cut down on studio time, and unlock entirely new music production workflows enabled by AI. Kits is backed by the best in music and tech, including Andreessen Horowitz (a16z), WndrCo, Electric Feel Ventures (EFC), 1Confirmation, Steve Aoki, 3LAU, Lionel Richie, Wyclef Jean & more.For more information please visit www.kits.ai
- Series unknown
- 11 employees
- Founded 2021
9
Alleviate Health· San Francisco, California, United States
Clinical trials recruitment is the largest bottleneck in drug development and site revenue growth. Alleviate Health accelerates recruitment speed with conversational AI that pre-screens patients over SMS that allows sites to drastically improve their output.
- Seed
- 10 employees
- Founded 2023
10
Vicinitas Therapeutics· South San Francisco, California, United States
Many diseases, including cancer and monogenic diseases, are often caused by specific proteins that are abnormally degraded and lost from the cell. In cancer, protective tumor suppressors are aberrantly destroyed, allowing cancer cells to circumvent cell death, thus promoting unobstructed cell proliferation. To date, many aberrantly degraded proteins have been considered “undruggable” or intractable to drug discovery efforts. Vicinitas Therapeutics is a biotechnology company focused on targeted protein stabilizers known as Deubiquitinase Targeting Chimeras (DUBTACs). The company’s mission is to use this proprietary technology to solve critical problems in human health by developing next-generation disease therapies against an entire class of previously inaccessible disease-causing proteins. Spun out of an academic-industry collaboration between Novartis Institutes for BioMedical Research and the University of California, Berkeley, Vicinitas Therapeutics is based in South San Francisco, California.
- Series A
- 3 employees
- Founded 2022

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Andreessen Horowitz-backed AI companies in San Francisco

The list above ranks Andreessen Horowitz-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 10 matching companies in Refolk’s index, you can see exactly where Andreessen Horowitz’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Andreessen Horowitz AI world in San Francisco.

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How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Andreessen Horowitz, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Mon, 17 Aug 2026 07:50:02 GMT

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