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Andreessen Horowitz AI portfolio in San Francisco

Multi-stage venture firm investing across consumer, enterprise, fintech, and crypto. Filtered to AI companies headquartered in San Francisco.

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Built from a search like: “Andreessen Horowitz-backed AI companies in San Francisco”

Ranked by current headcount across Andreessen Horowitz-backed AI companies in San Francisco. Refreshed monthly.

  1. 1
    OpenAI· San Francisco, California, United States

    OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

    • Series unknown
    • 10.7k employees
    • Founded 2015
  2. 2
    Arena· San Francisco, California, United States

    Created by researchers from UC Berkeley, Arena (formerly LMArena) is a community-powered platform to measure and advance the frontier of AI for real-world use. Tens of millions of builders, researchers, and creative professionals come to Arena to use frontier models and give feedback on their responses, shaping a public leaderboard grounded in real-world use.

    • Series A
    • 96 employees
    • Founded 2025
  3. 3
    Phylo· South San Francisco, California, United States

    Phylo is an applied research lab dedicated to studying agentic intelligence to accelerate discoveries for every biomedical scientist. Building Biomni Lab - the first integrated biology environment.

    • Seed
    • 19 employees
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  5. 4
    QuiverAI· San Francisco, California, United States

    An AI research and product company building world-class models and tools for vector generation and editing.

    • Seed
    • 16 employees
    • Founded 2025
  6. 5
    Alleviate Health· San Francisco, California, United States

    Clinical trials recruitment is the largest bottleneck in drug development and site revenue growth. Alleviate Health accelerates recruitment speed with conversational AI that pre-screens patients over SMS that allows sites to drastically improve their output.

    • Seed
    • 12 employees
    • Founded 2023
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Andreessen Horowitz-backed AI companies in San Francisco

The list above ranks Andreessen Horowitz-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 7 matching companies in Refolk’s index, you can see exactly where Andreessen Horowitz’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Andreessen Horowitz AI world in San Francisco.

Refolk converts this list into a live search. Ask for “Andreessen Horowitz AI companies in San Francisco hiring senior engineers” or “founders of Andreessen Horowitz-backed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Andreessen Horowitz, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Tue, 22 Sep 2026 14:08:58 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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