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Khosla Ventures AI portfolio in San Francisco

Vinod Khosla's firm - deeptech, climate, healthcare, and contrarian software bets. Filtered to AI companies headquartered in San Francisco.

Built from a search like: Khosla Ventures-backed AI companies in San Francisco

Ranked by current headcount across Khosla Ventures-backed AI companies in San Francisco. Refreshed daily.

  1. 1
    OpenAI· San Francisco, California, United States

    OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

    • Series unknown
    • 10.5k employees
    • Founded 2015
  2. 2
    Loyal· San Francisco, California, United States

    Loyal Animal Health, Inc. is a clinical-stage veterinary medicine company developing drugs intended to extend the lifespan and healthspan of dogs. In other words, our mission is to help dogs live longer, healthier lives.We’ve already achieved significant milestones on our path to gaining FDA approval for the first lifespan extension drug for any species. Our team includes scientists, veterinarians, engineers, operators, and creatives. Join us in our mission to help dogs everywhere.

    • Series C
    • 212 employees
    • Founded 2020
  3. 3
    NewLimit· South San Francisco, California, United States

    NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.All correspondence from NewLimit will come from an @NewLimit.com email address.

    • Series C
    • 55 employees
    • Founded 2022
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  5. 4
    NOETIK· South San Francisco, California, United States

    NOETIK is a bio AI company building foundation models of human biology to redefine clinical outcomes in oncology. From the largest proprietary multimodal human dataset of its kind, NOETIK's foundation models precisely match therapeutic targets to patient populations, enable target ID, and predict clinical efficacy. By partnering with clinical developers and pharmaceutical partners such as GSK, NOETIK is deploying the AI infrastructure layer for translational medicine and co-developing therapeutics with the potential for a higher probability of clinical success. To learn more about Noetik, visit https://www.noetik.ai

    • Grant
    • 51 employees
    • Founded 2022
  6. 5
    Vivodyne· San Francisco Bay Area

    🧬🤖🖥 Vivodyne accelerates the discovery of cures to human diseases with highly scalable drug testing on lab-grown 3D human tissues.

    • Series A
    • 40 employees
    • Founded 2020

Khosla Ventures-backed AI companies in San Francisco

The list above ranks Khosla Ventures-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 13 matching companies in Refolk’s index, you can see exactly where Khosla Ventures’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Khosla Ventures AI world in San Francisco.

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How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Khosla Ventures, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 14:03:56 GMT

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The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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