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Sequoia Capital AI portfolio in San Francisco

Storied venture firm backing seed through pre-IPO across software and infrastructure. Filtered to AI companies headquartered in San Francisco.

Built from a search like: Sequoia Capital-backed AI companies in San Francisco

Ranked by current headcount across Sequoia Capital-backed AI companies in San Francisco. Refreshed daily.

  1. 1
    OpenAI· San Francisco, California, United States

    OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

    • Series unknown
    • 10.5k employees
    • Founded 2015
  2. 2
    Xaira Therapeutics· South San Francisco, California, United States

    Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease. We seek to rethink the drug discovery and development process from end-to-end by bringing together leading talent across three core areas: machine learning research to better understand biology, expansive data generation to power new models, and robust therapeutic product development to treat disease. Xaira is headquartered in the San Francisco Bay Area.Please be advised that we will never ask for personal information or any financial commitment from a candidate as a pre-employment requirement. All legitimate Xaira communication regarding our recruitment processes comes from email addresses ending with @xaira.com or through recognized professional networks, such as LinkedIn. To avoid any potential fraudulent activity, please make sure to apply only through Xaira's official Careers page: https://www.xaira.com/work-with-us

    • Series A
    • 214 employees
    • Founded 2023
  3. 3
    Algen Biotechnologies· San Francisco, California, United States

    Revolutionizing therapeutic drug discovery through advanced CRISPR gene-modulation and AI

    • Seed
    • 18 employees
    • Founded 2018
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  5. 4
    Engram· San Francisco, California, United States

    Scaling compute on your context.

    • Seed
    • 16 employees
  6. 5
    Stemcentrx, Inc.· South San Francisco, California, United States

    Founded in 2008, Stemcentrx combines state-of-the-art research and GMP manufacturing capabilities. This has allowed us to advance from target discovery in our laboratory to treating patients in clinical trials at an accelerated pace. We are investigating many of the largest and most lethal cancers through our proprietary platforms that identify cancer stem cells, discover novel targets, engineer and manufacture antibodies and antibody drug conjugates.Our mission is to develop therapies that cure and significantly improve survival for cancer patients. We are pioneering new approaches to eliminate cancer stem cells, which initiate and perpetuate tumors. Stemcentrx has assembled a talented and motivated team committed to this mission. We are recruiting people with world-class expertise in their practice, versatility, high energy and an entrepreneurial spirit. Our state-of-the-art laboratories and manufacturing facilities are located in South San Francisco, California. We have a driven, ambitious, focused, hard-working, apolitical, fun, and collaborative culture that is more typical of Silicon Valley startups than large pharmaceutical companies. Our employees are compensated with salary, benefits and stock options.

    • Series G
    • 6 employees
    • Founded 2008

Sequoia Capital-backed AI companies in San Francisco

The list above ranks Sequoia Capital-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 5 matching companies in Refolk’s index, you can see exactly where Sequoia Capital’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Sequoia Capital AI world in San Francisco.

Refolk converts this list into a live search. Ask for Sequoia Capital AI companies in San Francisco hiring senior engineers” or “founders of Sequoia Capital-backed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Sequoia Capital, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 13:00:07 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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The underlying index updates continuously and this page re-renders at least daily. Last refreshed: Wed, 05 Aug 2026 13:00:07 GMT.

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