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Sequoia Capital AI portfolio in San Francisco

Storied venture firm backing seed through pre-IPO across software and infrastructure. Filtered to AI companies headquartered in San Francisco.

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Built from a search like: “Sequoia Capital-backed AI companies in San Francisco”

Ranked by current headcount across Sequoia Capital-backed AI companies in San Francisco. Refreshed monthly.

  1. 1
    OpenAI· San Francisco, California, United States

    OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

    • Series unknown
    • 10.5k employees
    • Founded 2015
  2. 2
    Engram· San Francisco, California, United States

    Scaling compute on your context.

    • Seed
    • 16 employees

Sequoia Capital-backed AI companies in San Francisco

The list above ranks Sequoia Capital-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 2 matching companies in Refolk’s index, you can see exactly where Sequoia Capital’s AI thesis has landed in San Francisco.

Three filters - investor, industry, city - narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Sequoia Capital AI world in San Francisco.

Refolk converts this list into a live search. Ask for “Sequoia Capital AI companies in San Francisco hiring senior engineers” or “founders of Sequoia Capital-backed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Sequoia Capital, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Mon, 14 Sep 2026 16:07:28 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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The underlying index updates continuously and this ranking is rebuilt monthly. Last refreshed: Mon, 14 Sep 2026 16:07:28 GMT. For a list built against the index as it stands today, sign up and run the search live.

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