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Sequoia Capital AI portfolio in San Francisco

Storied venture firm backing seed through pre-IPO across software and infrastructure. Filtered to AI companies headquartered in San Francisco.

Built from a search like: “Sequoia Capital-backed AI companies in San Francisco”

Ranked by current headcount across Sequoia Capital-backed AI companies in San Francisco. Refreshed daily.

  1. 1
    OpenAI· San Francisco, California, United States
    • Series unknown
    • 7.8k employees
    • Founded 2015
  2. 2
    Xaira Therapeutics· South San Francisco, California, United States
    • Series A
    • 192 employees
    • Founded 2023
  3. 3
    Algen Biotechnologies· San Francisco, California, United States
    • Seed
    • 16 employees
    • Founded 2018
  4. 4
    Stemcentrx, Inc.· South San Francisco, California, United States
    • Series G
    • 6 employees
    • Founded 2008

Sequoia Capital-backed AI companies in San Francisco

The list above ranks Sequoia Capital-backed AI companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 4 matching companies in our index, you can see exactly where Sequoia Capital’s AI thesis has landed in San Francisco.

Three filters — investor, industry, city — narrow the field to a tight cluster of operators with overlapping incentives. They share a thesis, a network, and a market. Hiring from this list usually means hiring someone already inside the Sequoia Capital AI world in San Francisco.

Refolk converts this list into a live search. Ask for “Sequoia Capital AI companies in San Franciscohiring senior engineers” or “founders of Sequoia Capital-backed AI companies in San Francisco who left in the last year” and Refolk returns a ranked shortlist.

How this list is built

Refolk pulled AI companies headquartered in San Francisco whose disclosed Crunchbase investor list includes Sequoia Capital, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Thu, 07 May 2026 08:01:09 GMT

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