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Greylock portfolio AI companies

Early-stage venture firm with a strong enterprise and AI footprint. Filtered to companies in AI.

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Built from a search like: “Greylock-backed AI companies”

Ranked by current headcount across Greylock-backed AI companies. Refreshed monthly.

  1. 1
    Vertex Pharmaceuticals· Boston, Massachusetts, United States

    Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and has made significant advancements in cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, and acute pain — and continues to progress clinical and research programs in these diseases. We also have a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where we have deep insight into causal human biology, including acute and neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy, autosomal dominant polycystic kidney disease, type 1 diabetes and myotonic dystrophy type 1. Our global headquarters is in Boston, and we have research and development (R&D) sites and commercial offices worldwide.Vertex is consistently recognized as one of the industry’s top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. We have also earned a spot on TIME Most Influential Companies, TIME Best Inventions, and Fast Company Most Innovative Companies lists. Our research and medicines have received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the Prix Galien, the Scrip Award and the Breakthrough Prize awards.Read our community guidelines: https://www.vrtx.com/vertexs-community-guidelines/

    • Post-IPO debt
    • 6.5k employees
    • Founded 1989
  2. 2
    BIOPTIC· San Francisco, California, United States

    AI-powered drug discovery platform for rapid molecule screening and testing, from target identification to lab validation. Automating biotech R&D.About Optic Optic started as an AI research team developing high-performance similarity search algorithms. Today our proprietary AI-technology is powering products in multiple industries from blockchain to biotech.

    • Seed
    • 292 employees
    • Founded 2021
  3. 3
    Manas AI

    Disrupting drug development.

    • Seed
    • 32 employees
    • Founded 2025
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  5. 4
    Atomic AI· San Francisco, California, United States

    At Atomic AI, we build artificial intelligence to pioneer new frontiers in drug discovery. Our unique R&D platform, an early version of which was featured on the cover of Science, enables the design of novel, RNA‐centric medicines for areas of high unmet need. We continue to advance this platform by developing new machine learning methods and unique foundation models fueled by our large-scale, in-house experimental data collection. We are an interdisciplinary team of scientists and engineers and believe our people are our greatest strength and the key to our success.

    • Series A
    • 27 employees
    • Founded 2021

Greylock’s AI portfolio

The list above ranks Greylock-backed AI companies by current headcount, drawn from public LinkedIn and Crunchbase records. 4 matching companies in Refolk’s index give you a quick read on where Greylock has gone deepest in the AI space.

Greylock’s AI bets tend to share a thesis. The engineers, ML researchers, and founders inside these companies are often building the same primitives - and they show up in AI talent pools across the next decade.

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How this list is built

Refolk pulled AI companies whose disclosed Crunchbase investor list includes Greylock, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes monthly.

Last refreshed: Thu, 01 Oct 2026 01:12:55 GMT

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The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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