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Top AI companies in the United States

Companies building AI products, foundation models, and applied ML platforms. Filtered to companies headquartered in the United States.

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Built from a search like: “Top AI companies in the United States”

Ranked by current headcount across AI companies headquartered in the United States. Refreshed daily.

  1. 1
    Thermo Fisher Scientific· Waltham, Massachusetts, United States
    • Post-IPO debt
    • 100.4k employees
    • Founded 1956
  2. 2
    Amgen· Thousand Oaks, California, United States
    • Post-IPO debt
    • 40.3k employees
    • Founded 1980
  3. 3
    The National Institutes of Health· Bethesda, Maryland, United States
    • Grant
    • 28.5k employees
  4. 4
    Syneos Health· Morrisville, North Carolina, United States
    • Private equity
    • 23.6k employees
    • Founded 1985
  5. 5
    PPD· Waltham, Massachusetts, United States
    • Private equity
    • 20.4k employees
    • Founded 1985
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Find engineers at AI companies in the United States

the United States has long been a hub for AI, and the list above ranks the largest AI companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 9,900 matching companies in our index, this is a good map of where the AI talent in the United Stateslives - useful whether you’re recruiting, partnering, or sizing a market.

The biggest AI companies in the United States tend to be the gravitational centres for specialised talent - senior engineers, ML researchers, applied scientists, designers - while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “AI engineers in the United Stateshiring senior staff” or “founders of AI companies in the United Stateswho left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled AI companies headquartered in the United States from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Sun, 21 Jun 2026 08:21:36 GMT

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