Top AI companies in the United States

Companies building AI products, foundation models, and applied ML platforms. Filtered to companies headquartered in the United States.

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Built from a search like: “Top AI companies in the United States”

Ranked by current headcount across AI companies headquartered in the United States. Refreshed daily.

1
Thermo Fisher Scientific· Waltham, Massachusetts, United States
About Thermo Fisher ScientificThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. For more information, please visit www.thermofisher.com.
- Post-IPO debt
- 101k employees
- Founded 1956
2
Amgen· Thousand Oaks, California, United States
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We helped establish the biotechnology industry, and we remain on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Our investment in research and development has yielded a robust pipeline that builds on our existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases.Amgen is one of 30 companies comprising the Dow Jones Industrial Average®, and part of the Nasdaq-100 Index®. In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes.For more information, visit Amgen.com and follow us on X, LinkedIn, Instagram, TikTok, YouTube and Threads. 🔗 Community Guidelines: https://wwwext.amgen.com/community-guidelines🔗Global Privacy Statement Directory: www.amgen.com/dpSpecial Advisory: Please be cautious of scam recruitment offers claiming to be from Amgen. Such scams may come from various sources, including fake websites and/or unsolicited emails and seek to obtain personal data or payment from victims by offering jobs that do not exist. Please be advised that Amgen would never ask for payment to progress a job application. When in doubt, please check to see if the position in question is posted on this website before applying. Additionally, please report any suspicious recruiting activity to https://complaint.ic3.gov/ and thank you for your assistance.
- Post-IPO debt
- 41.4k employees
- Founded 1980
3
The National Institutes of Health· Bethesda, Maryland, United States
NIH is the only agency of its kind. We impact the health of the country and the world through unique and innovative medical research. Did you know that NIH is the largest public funder of biomedical research in the world, investing more than $32 billion a year to enhance life, and reduce illness and disability? NIH funded research has led to breakthroughs and new treatments, helping people live longer, healthier lives, and building the research foundation that drives discovery.Whether you are graduating with a bachelor's degree, working on your doctoral degree, entering the workforce for the first time, or changing careers, NIH offers a place for you to start and plenty of room to grow your career.When you join us, you’re not just advancing your career — you’re driving the health of our country forward.Official LinkedIn Account of the NIH. Privacy policy: http://go.usa.gov/x9svNComment policy: https://bit.ly/3G6xq94Engagement ≠ endorsement
- Grant
- 28.7k employees
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4
Syneos Health· Morrisville, North Carolina, United States
Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, commercial and real world insights into outcomes to address modern market realities. We bring together a talented team of professionals with a deep understanding of patient and physician behaviors and market dynamics. Together we share diverse insights, use the latest technologies and apply advanced business practices to speed our customers’ delivery of important therapies to patients.Syneos Health is powered by an authentic, inclusive and high-performance culture that cares for colleagues, customers, patients, communities and the environment.
- Private equity
- 23.8k employees
- Founded 1985
5
PPD· Waltham, Massachusetts, United States
The PPDTM clinical research business of Thermo Fisher Scientific, the world leader in serving science, enables customers to accelerate innovation and drug development through patient-centered strategies and data analytics. Our services, which span multiple therapeutic areas, include early development, all phases of clinical development, peri- and post-approval, patient recruitment, investigator sites and comprehensive laboratory services. As a global industry leader, we offer custom solutions to pharma, biotech, medical device, and government organizations, leveraging cutting-edge technology and therapeutic expertise to help customers deliver life-changing therapies.
- Private equity
- 20.2k employees
- Founded 1985

6
Genentech· South San Francisco, California, United States
About GenentechWe're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal.Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683)Monday-Friday, 6am-5pm PST or patientinfo@gene.com. Community Guidelines:1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages.2. Don’t mention any medicines by name — ours or anyone else’s.Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments.3. This isn’t the place to report or discuss side effects.This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.4. Don’t pitch your product or service.Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
- Series A
- 18.3k employees
- Founded 1976
7
Agilent Technologies· Santa Clara, California, United States
Agilent customers are finding new ways to treat cancer, ensure food, water, air, and medicine quality and safety, discover new drug treatments, research infectious diseases, and create alternative energy solutions for a greener planet. From start to finish, we have them covered with our vast product solutions and services portfolio.Around the world, Agilent’s people bring innovations, technologies, and services to the forefront of science. Our teams design and manufacture a wide array of advanced analytical, research, and diagnostic solutions and tools for use inside and outside laboratories.Additionally, the unique expertise of Agilent’s CrossLab and technical teams provides valuable insight and support to our customers, helping them fully optimize their laboratories and resources to better focus on what's important: bringing great science to life.In fiscal 2022, Agilent Technologies generated revenue of (US) $6.85 billion.
- Post-IPO debt
- 18.2k employees
- Founded 1999
8
Gilead Sciences· San Mateo, California, United States
At Gilead, we set – and achieve – bold ambitions to create a healthier world for all people. From our pioneering virology medicines to our growing impact in oncology, we're delivering innovations once thought impossible in medicine. Our focus goes beyond medicines, and we also strive to remedy health inequities and break down barriers to care. We empower our people to tackle these challenges, and we’re all united in our commitment to help millions of people live healthier lives.Social Media Guidelines: https://www.gilead.com/social-media-guidelines
- Post-IPO debt
- 14.8k employees
- Founded 1987
9
Charles River Laboratories· Wilmington, Massachusetts, United States
At Charles River, we are guided by our strong purpose—to create healthier lives—which centers around the patients who rely on the therapeutics we help to develop, the animals in our care, to our planet, and to the passionate and skilled people who are at the heart of our organization and make it all possible. #DrugDiscovery #Biotech #Biotechnology #Pharmaceuticals #CRL
- Grant
- 14.5k employees
- Founded 1947
10
Los Alamos National Laboratory· Los Alamos, New Mexico, United States
Los Alamos National Laboratory is one of the world’s most innovative multidisciplinary research institutions. We're engaged in strategic science on behalf of national security to ensure the safety and reliability of the U.S. nuclear stockpile. Our workforce specializes in a wide range of progressive science, technology and engineering across many exciting fields, including space exploration, geophysics, renewable energy, supercomputing, medicine and nanotechnology.
- Grant
- 13.7k employees
- Founded 1943

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Find engineers at AI companies in the United States

the United States has long been a hub for AI, and the list above ranks the largest AI companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 10,111 matching companies in Refolk’s index, this is a good map of where the AI talent in the United States lives - useful whether you’re recruiting, partnering, or sizing a market.

The biggest AI companies in the United States tend to be the gravitational centres for specialised talent - senior engineers, ML researchers, applied scientists, designers - while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “AI engineers in the United States hiring senior staff” or “founders of AI companies in the United States who left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled AI companies headquartered in the United States from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 09:26:30 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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The underlying index updates continuously and this page re-renders at least daily. Last refreshed: Wed, 05 Aug 2026 09:26:30 GMT.

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