Top AI companies in Seattle

Companies building AI products, foundation models, and applied ML platforms. Filtered to companies headquartered in Seattle.

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Ranked by current headcount across AI companies headquartered in Seattle. Refreshed monthly.

1
Allen Institute· Seattle, Washington, United States
We do science differently—bigger, bolder, and built to be shared with the world. From mapping every cell in the brain to decoding how the immune system fights disease and beyond, we operate at a scale designed to generate resources the entire scientific community can build on. Our commitment to open science means every breakthrough belongs to everyone.
- Grant
- 1.5k employees
- Founded 2003
2
Just - Evotec Biologics· Seattle, Washington, United States
Just – Evotec Biologics, a wholly owned subsidiary of Evotec SE, is an innovative and trusted CDMO for complex biologics, incl. mAbs, bi/multispecifics, and biosimilars. We provide our partners with highly differentiated services for the development and manufacturing of biologics. Our world-leading AI-driven in silico molecular optimization and continuous bioprocessing platforms combined with our revolutionary J.POD® facilities, which represent a paradigm shift within the industry, are helping to reduce the cost of goods and expand global access to affordable, high-quality biotherapeutics in addition to providing a highly agile cGMP manufacturing strategy to support rapid ramp up and uncertain demand scenarios.
- Grant
- 604 employees
- Founded 2014
3
University of Washington School of Public Health· Seattle, Washington, United States
The UW School of Public Health, ranked among the top 10 public health schools in the United States, is grounded in teaching, research and service. For more than 50 years, our 10,000+ graduates have gone on to transform communities, lead health organizations and find solutions to emerging public health challenges.
- 315 employees
- Founded 1970
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4
Benaroya Research Institute· Seattle, Washington, United States
Benaroya Research Institute (BRI) is powering discoveries in order to learn how to rebalance the immune system in all autoimmune and immune system diseases. Our ultimate goal is to achieve a healthy immune system for each individual. Affiliated with Virginia Mason Franciscan Health.As a world-renowned, non-profit research institute we advance science that will predict, prevent, reverse and cure diseases of the immune system. Our Centers for Discovery accelerate progress through laboratory breakthroughs in immunology that can be translated to clinical therapies.
- Grant
- 313 employees
- Founded 1956
5
Institute for Systems Biology (ISB)· Seattle, Washington, United States
ISB is a collaborative and cross-disciplinary non-profit biomedical research organization based in Seattle. We focus on some of the most pressing issues in human health, including aging, cancer, COVID, the gut microbiome, and many chronic and infectious diseases. Our science is translational, and we champion sound scientific research that results in real-world clinical impacts. ISB is an affiliate of Providence, one of the largest not-for-profit health care systems in the United States.
- Grant
- 287 employees
- Founded 2000

6
Sana Biotechnology, Inc.· Seattle, Washington, United States
Sana Biotechnology is focused on utilizing engineered cells as medicines for patients. The ability to modify genes and use cells as medicines will be one of the most important advances in healthcare over the next several decades. Sana is building differentiated capabilities across the spectrum of cell and gene therapy. Three aspirations drive Sana as we look to discover treatments for patients with poor outcomes or currently untreatable diseases. The first is the ability to repair and control the genes in any cell in the body. We are advancing novel delivery technologies with the goal of being able to deliver any payload to any cell in a specific, predictable, and repeatable manner, paving the way for next-generation in vivo gene therapy. Next is the ability to differentiate pluripotent stem cells ex vivo into immune-cloaked functional cells with the aspiration of being able to replace any missing or damaged cells in the body. Last is a belief we can enable broader access to our therapies through focusing on scalable manufacturing solutions, the cost of manufacturing, and aligning with key stakeholders. Sana launched in early 2019 and has over 350 employees in Seattle, Cambridge, and South San Francisco. Sana was founded with the long view – bringing together great people and the best technologies to deliver on the challenging promise of using engineered cells to meaningfully change the outcome of many human diseases.
- Post-IPO equity
- 252 employees
- Founded 2018
7
Umoja Biopharma· Seattle, Washington, United States
Umoja is developing a new approach to immunotherapy that aims to retool a patient’s immune system in vivo, enhancing the body’s natural capacity to fight diseases.
- Series C
- 250 employees
- Founded 2019
8
Unknown· Seattle, Washington, United States
Our mission at the Allen Institute for Brain Science is to accelerate the understanding of how the brain works in health and disease. Using a big science, team science, open science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory.
- 229 employees
- Founded 2003
9
Omeros Corporation· Seattle, Washington, United States
Omeros is a Seattle-based biopharmaceutical company committed to discovering, developing, and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, coagulopathies, and disorders of the central nervous system.
- Post-IPO equity
- 222 employees
- Founded 1994
10
NanoString Technologies, Inc.· Seattle, Washington, United States
NanoString Technologies, a Bruker Company, is a provider of life science tools for translational research. The company's technology enables a wide variety of basic research and translational medicine applications.NanoString's products are based on a novel digital molecular barcoding technology invented at the Institute for Systems Biology (ISB) in Seattle under direction of Dr. Leroy Hood. The company was founded in 2003 with an exclusive license to develop and market the technology. In 2008, NanoString launched its first commercial instrument system and began international sales operations with its first multiplexed assays for gene expression analysis. In 2010, the company launched new applications for the system to support microRNA analysis and gene expression detection. In 2019, the company launched the GeoMxTM Digital Spatial Profiler enabling highly-multiplexed spatial profiling of RNA and protein targets in a variety of sample types, including FFPE tissue sections. In 2022, the company launched CosMxTM Spatial Molecular Imager, enabling the first high-plex in situ analysis platform to provide spatial multi-omics with formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples at cellular and subcellular resolution. CosMx SMI is a flexible, spatial single-cell imaging platform that will drive deeper insights for cell atlasing, tissue phenotyping, cell-cell interactions, cellular processes, and biomarker discovery. In 2022, AtoMxTM Spatial Informatics Platform (SIP), the only cloud-based, fully-integrated informatics platform for spatial biology, was also launched.In 2024, NanoString Technologies has been acquired by Bruker Corporation, a leading global provider of scientific instruments and solutions. This strategic acquisition marks the beginning of a promising new chapter for NanoString and our valued customer.
- Post-IPO debt
- 221 employees
- Founded 2003

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Find engineers at AI companies in Seattle

Seattle has long been a hub for AI, and the list above ranks the largest AI companies headquartered there by current headcount, drawn from public LinkedIn and Crunchbase records. With 144 matching companies in Refolk’s index, this is a good map of where the AI talent in Seattle lives - useful whether you’re recruiting, partnering, or sizing a market.

The biggest AI companies in Seattle tend to be the gravitational centres for specialised talent - senior engineers, ML researchers, applied scientists, designers - while the smaller ones compete on speed, equity, and proximity to founders.

Refolk converts this list into a live search. Ask for “AI engineers in Seattle hiring senior staff” or “founders of AI companies in Seattle who left in the last 12 months” and Refolk returns a ranked shortlist with the evidence that earned each person a spot.

How this list is built

Refolk pulled AI companies headquartered in Seattle from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 10 employees. The list refreshes monthly.

Last refreshed: Fri, 16 Oct 2026 19:07:41 GMT

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The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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