Series C AI companies in San Francisco

Companies building AI products, foundation models, and applied ML platforms. Filtered to Series C-stage companies headquartered in San Francisco.

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Ranked by current headcount across Series C AI companies in San Francisco. Refreshed daily.

1
insitro· South San Francisco, California, United States
insitro is the physical AI company unlocking causal human biology, founded and led by AI pioneer Daphne Koller. By generating the world’s largest integrated multi-modal corpus of human and cellular data, we’ve built the Virtual HumanTM – a genetically anchored causal AI engine that reveals how disease begins, progresses, and can be resolved. Our platform enables us to precisely identify causal genetic drivers and deploy our TherMLTM AI platform to design optimal medicines, advancing a broad pipeline of therapeutics for neuroscience and metabolic diseases. This industrialized architecture creates a self-learning loop: with every biology we onboard, our predictive models grow smarter, accelerating discovery across scales of biology.Join us in transforming the future of medicine!
- Series C
- 256 employees
- Founded 2018
2
Loyal· San Francisco, California, United States
Loyal Animal Health, Inc. is a clinical-stage veterinary medicine company developing drugs intended to extend the lifespan and healthspan of dogs. In other words, our mission is to help dogs live longer, healthier lives.We’ve already achieved significant milestones on our path to gaining FDA approval for the first lifespan extension drug for any species. Our team includes scientists, veterinarians, engineers, operators, and creatives. Join us in our mission to help dogs everywhere.
- Series C
- 212 employees
- Founded 2020
3
Arsenal Biosciences, Inc.· South San Francisco, California, United States
ArsenalBiosciences, Inc., is a clinical stage programmable cell therapy company focused on the realization of solid tumor cell therapy to defeat cancer. Our discovery engine comprises precise CRISPR-enabled genome editing, integrated circuits incorporating logic gates for improved tumor targeting, and therapeutic enhancements enabling multiple pharmaceutical functions. With our programmable and computationally driven approach, we aim for enhanced and broader efficacy, increased patient safety, reduced provider costs and expanded market access. Our team is engineering living medicines to attack cancer’s inherent multi-faceted nature and bring dramatic improvements to the lives of patients.
- Series C
- 178 employees
- Founded 2019
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4
Frontier Medicines· South San Francisco, California, United States
Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Our lead program targets both the activated and inactive forms of KRAS G12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of bolding advancing science to defeat disease, starting with cancer.
- Series C
- 78 employees
- Founded 2018
5
Unlearn.AI· San Francisco, California, United States
Unlearn exists to transform clinical development by making every trial smarter.
- Series C
- 75 employees
- Founded 2017

6
Culture Biosciences· South San Francisco, California, United States
Culture is your bioreactor lab, in the cloud.We help scientists accelerate bioprocess development with our high-throughput bioreactor cloud lab. You design your experiment, and we execute the experiment in our lab using our 250mL bioreactors. We take care of the high-quality execution so that you can focus on developing processes. While your experiment runs in our lab, you can monitor and analyze your data in real time using our online dashboard. With Culture, get faster insights to make better, data-driven decisions.
- Series C
- 67 employees
- Founded 2016
7
NewLimit· South San Francisco, California, United States
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.All correspondence from NewLimit will come from an @NewLimit.com email address.
- Series C
- 55 employees
- Founded 2022
8
InterVenn Biosciences· South San Francisco, California, United States
We are leveraging artificial intelligence to map the glycoprotein control points that orchestrate disease progression—the missing link that genomics and proteomics can't see.We are focused on decoding the glycoproteome as a rich source of biological insight. Thanks to the use of artificial intelligence (AI), we have pioneered a proprietary technology platform, GlycoVisionTM, to tap into this layer of biology at a clinically meaningful scale. GlycoVision is capable of producing a robust pipeline of powerful clinical applications, ranging from early disease screening to diagnostics and potentially therapeutics. The GlycoVision platform is accessible to industry partners seeking to discover novel biomarkers from as little as 50 μL of serum or plasma.
- Series C
- 49 employees
- Founded 2017
9
Terremoto Biosciences· South San Francisco, California, United States
Terremoto Biosciences is a covalent drug discovery and development engine creating highly targeted, small molecule medicines with unmatched selectivity, potency and efficacy. The company leverages the power of lysine-based covalency across the disease spectrum to develop both best-in-class therapies against known drug targets and first-in-class medicines against the previously undruggable. Many of Terremoto’s founders helped establish this emergent area of science, with the intent to broaden the number of tractable targets and deliver medicines with superior therapeutic benefit. Terremoto is supported by leading investors OrbiMed and Third Rock Ventures. More information is available at www.terremotobio.com.
- Series C
- 49 employees
- Founded 2021
10
Soley Therapeutics· South San Francisco, California, United States
Soley Therapeutics is a science-first, tech-enabled drug discovery and development company using cells as the world’s most powerful sensors to uncover first-in-class medicines. Soley’s platform translates the cellular information of stress biology into mechanistic insight, revealing novel drug candidates that otherwise would be missed. Soley deploys full-stack AI via its collaboration with Oracle, including OCI AI Infrastructure, NVIDIA AI Enterprise and NVIDIA Blackwell GPUs. By combining foundational biology, proprietary imaging, first-in-class automation, and integrated AI tools, Soley has rapidly built a pipeline that spans oncology, neurodegenerative disorders, metabolic diseases, and other areas. Soley is headquartered in South San Francisco.
- Series C
- 40 employees
- Founded 2020

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Find engineers at Series C AI companies in San Francisco

Searching for “engineers at top Series C AI companies in San Francisco” surfaces this slice of the market. The list above ranks AI companies headquartered in San Francisco whose latest disclosed round is Series C, by current headcount, drawn from public LinkedIn and Crunchbase records. With 18 matching companies in Refolk’s index, this is a tight read on where the AI talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series C, AI, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become AI’s next operators and angel investors.

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Refolk pulled AI companies headquartered in San Francisco whose latest disclosed funding round is Series C from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 14:21:05 GMT

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