Top Series A companies in San Francisco

Companies that have closed a Series A - product-market fit confirmed and scaling. Filtered to companies headquartered in San Francisco.

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Ranked by current headcount across Series A companies headquartered in San Francisco. Refreshed daily.

1
Genentech· South San Francisco, California, United States
About GenentechWe're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal.Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683)Monday-Friday, 6am-5pm PST or patientinfo@gene.com. Community Guidelines:1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages.2. Don’t mention any medicines by name — ours or anyone else’s.Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments.3. This isn’t the place to report or discuss side effects.This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.4. Don’t pitch your product or service.Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
- Series A
- 18.3k employees
- Founded 1976
2
Cambly Inc.· San Francisco, California, United States
The Cambly app gives English learners instant 1-on-1 access to friendly native speakers over video chat 24/7. Students get an affordable and convenient way to practice their English and gain confidence. Tutors get to make money helping people from around the world practice English.
- Series A
- 3k employees
- Founded 2012
3
Anything· San Francisco, California, United States
Anything turns English into apps.It's the AI product engineer for the next wave of entrepreneurs. Everything you need to make money on the internet built in.Our team is small and talent dense by design. We’ve built things people love. So we care that Anything lets anyone build things people love.
- Series A
- 2.9k employees
- Founded 2021
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4
Cookies· San Francisco, California, United States
Cookies' first-ever global coordinated drop, Fried Bananas, is available now.Cookies is the most globally recognized cannabis company; founded in 2010 by Billboard-charting rapper and entrepreneur Berner and Bay Area breeder and cultivator Jai. The company creates game-changing genetics and offers a collection of over 70 proprietary cannabis cultivars and more than 2,000 products. Headquartered in San Francisco, the company is actively involved in advocacy and social impact initiatives to enrich communities disproportionately impacted by the War on Drugs. Cookies opened its first retail store in 2018 in Los Angeles, has since expanded to over 70 retail locations in over 20 markets across 6 countries, and was recently named one of America's Hottest Brands of 2021 by AdAge; the first cannabis brand to ever receive this accolade. To learn more about Cookies, visit cookies.co. - CO excl. apply
- Series A
- 1.5k employees
- Founded 2010
5
Kaggle· San Francisco, California, United States
Kaggle is a global community of practitioners, researchers, and enthusiasts building and advancing the frontier of AI. Through AI competitions, benchmarks, and agentic evaluation, Kaggle provides a proving ground for community-led innovation.
- Series A
- 1.5k employees
- Founded 2010

6
Eco· San Francisco, California, United States
Eco is the stablecoin network that makes money programmable across every major blockchain. Leading companies use Eco to power stablecoin flows that require seamless user experience and best-in-class execution — cross-chain transfers and swaps, programmable flows, and more complex automations. Money simply moves smarter with Eco.
- Series A
- 1.5k employees
- Founded 2018
7
Cruise· San Francisco, California, United States
Cruise is building the world’s most advanced self-driving vehicles.Since our 2013 founding in San Francisco, we have hired over 1,600 talented individuals and opened additional offices in greater Seattle, Pasadena, Phoenix and Munich. We have raised $10B from General Motors, Honda, Microsoft, SoftBank, T. Rowe Price, Walmart and others. Through our partnerships with General Motors and Honda, we are the only self-driving company with fully integrated manufacturing at scale, building all-electric, zero-emission, self-driving vehicles that will help save lives, reimagine cities, reduce carbon pollution, redefine time in transit, and restore freedom of movement for individuals who live in dense urban settings.If you are looking to play a part in making a positive impact in the world by advancing the revolutionary work of self-driving vehicles, join us. getcruise.com/careers.
- Series A
- 1.4k employees
- Founded 2013
8
Villa· San Francisco, California, United States
Villa is California's #1 provider of prefab ADUs, primary residences and multifamily developments. We're leading the charge towards more affordable, high-quality housing with our industry-leading design tech and a turnkey process for planning, permitting, and installing prefab units. See what's possible at villahomes.com.CSLB#1077688 | HCD# DL1564605
- Series A
- 1.2k employees
- Founded 2019
9
Yummy· San Francisco, California, United States
Yummy (YC'S21) develops and manages the leading delivery and transportation app in Venezuela. Users can order rides, order delivery of anything, and purchase tickets for events.
- Series A
- 1.1k employees
- Founded 2020
10
Roo· San Francisco, California, United States
Roo is the largest veterinary relief network in the U.S. — and the first-of-its-kind platform built to transform the way relief work gets done. We connect veterinarians, vet techs, and animal hospitals through a modern, easy-to-use platform that puts control and flexibility back in their hands.We started Roo to solve a growing problem: veterinary professionals stretched to their limits and hospitals struggling to fill critical staffing gaps. Burnout, turnover, and overbooked schedules were hurting care teams and the pets they serve. We knew there had to be a better way — so we built it.With Roo, hospitals get fast access to a nationwide network of licensed vets and techs for relief coverage and recruitment, helping them reduce wait times, expand appointment availability, and support their teams — all without the overhead of traditional staffing solutions. Post shifts anytime, see transparent pricing before you commit, and choose who works at your hospital every time.For veterinary professionals, Roo means freedom. Set your schedule, choose where you work, and get paid quickly — all while earning more per hour than traditional roles and exploring clinics that match your values. Whether you're looking to regain work-life balance, supplement your income, or discover your next full-time home, Roo helps you get there.We're not just making relief work easier — we’re making veterinary careers more sustainable. By combining technology with a deep respect for the people behind the medicine, Roo is reimagining how staffing works — for the better.Say yes to more pets. Say yes to more balance. Say yes to Roo.
- Series A
- 787 employees
- Founded 2019

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Find engineers at Series A companies in San Francisco

Series A companies in San Francisco are some of the fastest-moving employers in the market. The list above ranks the largest Series A-stage companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 950 matching companies in Refolk’s index, the density of senior engineers, designers, and founders is unusually high.

At Series A, teams tend to be small, ambitious, and on the hunt for senior talent. The companies on this list are good signals for where the San Francisco talent market is heating up - and for which engineers and founders are about to become tomorrow’s operators.

Refolk converts this list into a live search. Ask for “founders of Series A companies in San Francisco” or “senior engineers at Series A companies in San Francisco hiring” and Refolk returns a ranked shortlist with evidence behind each match.

How this list is built

Refolk pulled Series A companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 13:09:42 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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