Top Late-stage venture companies in San Francisco

Series E and beyond - pre-IPO scaleups with hundreds of employees and meaningful revenue. Filtered to companies headquartered in San Francisco.

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Built from a search like: “Top Late-stage venture companies in San Francisco”

Ranked by current headcount across Late-stage venture companies headquartered in San Francisco. Refreshed monthly.

1
Genentech· South San Francisco, California, United States
About GenentechWe're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal.Making a difference in the lives of millions starts when you make a change in yours. If you’d like to join our team, view our openings at gene.com/careers. Our patient resource center is dedicated to getting patients and caregivers to the right resources. You can reach them at 1 (877) GENENTECH (436-3683)Monday-Friday, 6am-5pm PST or patientinfo@gene.com. Community Guidelines:1. We want to foster positive conversation around the issues we are passionate about. To that end, we remove profanity, content that contains threatening language, content that is aimed at private individuals, personal information, and repeated unwanted messages.2. Don’t mention any medicines by name — ours or anyone else’s.Because of the fair balance rules governing our industry, we cannot post any comments that reference any pharmaceutical brand, product, or service. Please do not mention any specific medicines by name, or include any links to third party sites in your comments.3. This isn’t the place to report or discuss side effects.This site is not intended as a forum for reporting side effects experienced while taking a Genentech product. Instead, you should report any side effects to Genentech Drug Safety at 1-888-835-2555. You can also report side effects of any prescription product directly to the FDA at 1-800-FDA-1088 or by visiting www.FDA.gov/medwatch.4. Don’t pitch your product or service.Please don't use our page as a place to promote your product or pitch your services. Please also avoid posting links to external sites. We reserve the right to remove any posts that are deemed promotional.
- Series unknown
- 18.2k employees
- Founded 1976
2
Handshake· San Francisco, California, United States
Handshake is the career network for the AI economy. 20 million knowledge workers, 1,600 educational institutions, 1 million employers (including 100% of the Fortune 500), and every foundational AI lab trust Handshake to power career discovery, hiring, and upskilling, from freelance AI training gigs to first internships to full-time careers and beyond.
- Series unknown
- 11.9k employees
- Founded 2014
3
Carta· San Francisco, California, United States
Carta powers interconnectivity in private markets — uniting data, people, and workflows in one connected system.We connect founders, investors, and limited partners through software purpose-built for private capital. Trusted by 50,000+ companies in 160+ countries, Carta’s platform of software and services lays the groundwork so you can build, invest, and scale with confidence.Carta’s Fund Administration platform supports 8,500+ funds and SPVs, representing nearly $185B in assets under management, with tools designed to enhance the strategic impact of fund CFOs. Carta has been included on the Fortune Best Large Workplaces in Financial Services and Insurance and Best Workplaces in the Bay Area lists, Forbes’ list of the World's Best Cloud Companies, Fast Company's Most Innovative list, Inc.'s Fastest-Growing Private Companies list, and is certified as a Great Place to Work for 2025-2026 (3 years running!). For more information, visit carta.com.
- Series unknown
- 11.7k employees
- Founded 2012
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4
OpenAI· San Francisco, California, United States
OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. AI is an extremely powerful tool that must be created with safety and human needs at its core. OpenAI is dedicated to putting that alignment of interests first — ahead of profit.To achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity. Our investment in diversity, equity, and inclusion is ongoing, executed through a wide range of initiatives, and championed and supported by leadership.At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.
- Series unknown
- 10.7k employees
- Founded 2015
5
Medium· San Francisco, California, United States
At Medium, we believe in the power of words — and we’re on a mission to bring the world’s expertise to life through memorable storytelling. Our platform rewards great writing and puts power back in the hands of readers. Medium’s subscription model means we rely on our members, not ads. We’re looking for teammates who are inspired by our mission, who are deeply thoughtful and empathetic, and who are passionate about the future of online publishing. Sound like you? Keep reading!
- Series unknown
- 9.8k employees
- Founded 2011

6
Deel· San Francisco, California, United States
Deel is one platform for payroll, HR, benefits, mobility, performance, and device management across 150+ countries. Built on owned infrastructure, powered by AI, and supported by thousands of local experts, Deel helps businesses scale smarter, faster, and more compliantly. Trusted by 40,000+ customers, and created to become a global brand people love. Learn more at deel.com.
- Series E
- 9.7k employees
- Founded 2019
7
SmartRecruiters· San Francisco, California, United States
SmartRecruiters was founded on the bold belief that great companies are built through great hiring. We began by helping organizations move beyond outdated systems with a modern, flexible applicant tracking system, designed to streamline hiring and support real business outcomes.We support more than 4,000 organizations in over 120 countries, helping them transform how they attract, select, and hire talent. But in 2024, it was clear: the challenge wasn’t just legacy software. The entire model of hiring needed to change. So we created something even better.Powered by Winston, our embedded AI hiring companion, and SmartOS, our adaptive talent operating system, SmartRecruiters delivers a fully connected, AI-native platform designed for speed, simplicity, and scale.In 2025, SmartRecruiters entered an exciting new chapter as we joined SAP, the global leader in enterprise applications. Together, we’re accelerating our vision of reinventing hiring by bringing the power of SmartRecruiters’ AI-native platform into the scale, reach, and resources of SAP’s ecosystem.
- Series E
- 9.7k employees
- Founded 2010
8
VIPKid· San Francisco, California, United States
VIPKid is a global education technology company that connects children with the world’s best teachers for real-time online English immersion learning. VIPKid’s mission is to inspire and empower every child for the future. VIPKid believes that education is not one-size-fits-all. Rather, all students are unique, and the world is within their reach when connected with great teachers capable of personalizing learning and sparking curiosity.Founded in 2013 and formally launched in 2014, VIPKid has become a market-leading online education startup, attracting investment from Tencent, Sequoia Capital, Yunfeng Capital, Coatue Management, Matrix Partners, Sinovation Ventures, Learn Capital, Northern Light VC, Bryant Stibel, among others.
- Series E
- 9k employees
- Founded 2013
9
Rippling· San Francisco, California, United States
Rippling is a workforce management system that eliminates the friction from running a business. Today, most companies struggle with everything from routine tasks, like running payroll, to cross-functional planning, like aligning on headcount. That’s because all their data related to people, processes, and systems is scattered in a hundred places. Rippling has every application you need to run your business—from applicant tracking and payroll to IT and expenses—in one place. But unlike other systems, Rippling sits on top of a unified platform. Data flows dynamically between Rippling’s applications, giving every team a shared source of truth, the power to automate processes, and access to the insights they need. This allows your business to execute better, faster.Based in San Francisco, CA, Rippling has raised $1.2B from the world’s top investors—including Kleiner Perkins, Founders Fund, Sequoia, Greenoaks, and Bedrock.Get help: rippling.com/contactLicensing details: https://app.rippling.com/licensing
- Series G
- 7.8k employees
- Founded 2016
10
Yelp· San Francisco, California, United States
Yelp connects people with great local businesses. Our users have contributed more than 265 million rich, local reviews of almost every type of local business, from restaurants, boutiques, and salons to dentists, mechanics, plumbers, and more. We are powered by a global community of collaborative people with shared values. Our employees are tenacious individuals who believe in our mission to connect people to great local businesses. In our remote-first workplace, your work makes a difference, you are seen as a whole person, and you are supported in your personal and professional growth. Your #FiveStarCareer starts here.
- Series E
- 7.3k employees
- Founded 2004

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Find engineers at Late-stage venture companies in San Francisco

Late-stage venture companies in San Francisco are some of the fastest-moving employers in the market. The list above ranks the largest Late-stage venture-stage companies headquartered in San Francisco by current headcount, drawn from public LinkedIn and Crunchbase records. With 895 matching companies in Refolk’s index, the density of senior engineers, designers, and founders is unusually high.

At Late-stage venture, teams tend to be small, ambitious, and on the hunt for senior talent. The companies on this list are good signals for where the San Francisco talent market is heating up - and for which engineers and founders are about to become tomorrow’s operators.

Refolk converts this list into a live search. Ask for “founders of Late-stage venture companies in San Francisco” or “senior engineers at Late-stage venture companies in San Francisco hiring” and Refolk returns a ranked shortlist with evidence behind each match.

How this list is built

Refolk pulled Late-stage venture companies headquartered in San Francisco from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 5 employees. The list refreshes monthly.

Last refreshed: Tue, 20 Oct 2026 19:24:37 GMT

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How is this ranking built?

The list draws on the public company graph - headcount and growth signals, funding history, and recency. The criteria chips at the top show exactly which filters produced it, and the methodology section explains the ranking.

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The underlying index updates continuously and this ranking is rebuilt monthly. Last refreshed: Tue, 20 Oct 2026 19:24:37 GMT. For a list built against the index as it stands today, sign up and run the search live.

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