Series B Biotech companies in San Francisco

Companies applying biology, chemistry, and computation to therapeutics and tooling. Filtered to Series B-stage companies headquartered in San Francisco.

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Ranked by current headcount across Series B Biotech companies in San Francisco. Refreshed daily.

1
Vial· San Francisco, California, United States
Vial is a next-generation pharma company. Focused on advancing a pipeline of potentially best-in-class biologics and RNA therapeutics across areas of unmet need.
- Series B
- 154 employees
- Founded 2020
2
Stämm· San Francisco, California, United States
Stämm is a biotechnology company dedicated to making biomanufacturing easy, scalable, sustainable, and repeatable. We are developing accessible, plug-and-play manufacturing solutions, allowing an automatized, continuous, and more efficient production of biologics and cell therapies.
- Series B
- 148 employees
- Founded 2016
3
Septerna· South San Francisco, California, United States
Septerna is on a mission to make the promise of future GPCR medicines a reality for patients. Combining the latest advances in biochemical, structural and computational drug discovery approaches, we have built an industrialized platform to precisely control and modulate GPCR biology and pharmacology to discover and develop new high-impact medicines. With our Native Complex PlatformTM, we are opening a new frontier in GPCR small molecule discovery technologies to expand the druggable GPCR landscape. We are always looking for talented scientists, drug hunters, and business professionals to join our mission to launch a new era of GPCR medicines. If you’re passionate about innovation, energized by teamwork, and fueled by the desire to change patient lives, join us and become a part of the Septerna story!
- Series B
- 138 employees
- Founded 2022
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4
Ohalo· South San Francisco, California, United States
To support a growing population efficiently, we need to shrink the land, water and energy footprint of our crops. Breeding is directed evolution, but it is slow and inefficient. Ohalo's technology shrinks the breeding cycles of plants. Our speed, accuracy and scalability create entirely new varieties of the world's most loved and consumed crops.
- Series B
- 122 employees
- Founded 2019
5
Human Longevity, Inc.· South San Francisco, California, United States
Human Longevity, Inc. TM (HLI) is the genomics-based, health intelligence company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries from these data to generate personalized health insights. Our goal is to extend healthy human life by revolutionizing human health and transforming the practice of medicine.Our DNA determines so much about each of us, but other factors can also influence our health. HLI is focused on compiling and analyzing more genotypic and phenotypic data because the combination of both enables us —to generate unprecedented insights and accelerate our understanding into what makes us who we are and what we can change for a life better lived.
- Series B
- 82 employees
- Founded 2013

6
Character Biosciences· San Francisco, California, United States
Character Biosciences is a precision medicine company transforming drug development for progressive, polygenic diseases, beginning with ophthalmology. Our mission is to identify the genetic and molecular drivers of disease progression so we can develop targeted therapies for patients who urgently need them. We've built one of the most comprehensive resources in age-related eye diseases by partnering with over 150 ophthalmology clinics to integrate genetics with longitudinal clinical and imaging data. This deep phenotyping approach enables us to reclassify complex diseases like age-related macular degeneration (AMD) into genetically defined subtypes, unlocking novel therapeutic targets and optimizing patient selection for clinical trials.Character Bio’s AI-powered platform combines genomics, multi-modal data, and machine learning to discover and develop therapies that are more precise and more effective. Our lead programs, CTX114 and CTX203, are advancing toward clinical trials and are designed to slow or prevent vision loss in AMD patients.We are committed to delivering a new generation of precision medicines to treat and ultimately cure age-related blindness.
- Series B
- 58 employees
- Founded 2019
7
SonoThera· South San Francisco, California, United States
SonoThera is developing ultrasound-mediated nonviral genetic therapies.
- Series B
- 57 employees
- Founded 2022
8
Epicrispr Biotechnologies· South San Francisco, California, United States
Epicrispr Biotechnologies is a biotechnology company developing ultracompact therapies to modulate gene expression in vivo using the smallest known Cas protein, CasMINI.
- Series B
- 48 employees
- Founded 2018
9
T-knife Therapeutics· San Francisco, California, United States
T-knife is a clinical-stage biotechnology company developing next-generation engineered T cell therapies and in vivo cell therapies for solid tumors. The company combines proprietary engager technology, synthetic biology, and a deep understanding of solid tumors to create armored supercharged T cell therapies designed to achieve broad, deep, and durable responses for patients in high unmet-need indications.T-knife’s lead oncology program, TK-6302, is a potentially best-in-class engineered TCR-T cell therapy targeting PRAME, a clinically validated cancer antigen expressed across multiple high-value solid tumor indications, including ovarian cancer, melanoma, non-small cell lung cancer (NSCLC), endometrial cancer, and triple-negative breast cancer (TNBC). TK-6302 has been specifically designed to overcome barriers in the solid tumor microenvironment leading to improved persistence of highly functional T-cells.T-knife is also advancing two proprietary in vivo cell therapy programs for solid tumors aimed at reprogramming immune cells directly within the patient. These first- and best-in-class in vivo T cell therapy candidates are leveraging the company's broad solid tumors technology toolbox and incorporate innovative designs to improve in vivo cell therapy efficacy in solid tumors.Founded by leading experts in T cell biology, immunology, and cancer immunotherapy, T-knife was built on pioneering research from the Max Delbrück Center for Molecular Medicine and Charité – Universitätsmedizin Berlin. The company is led by an experienced biotech leadership team and backed by leading global life science investors, including Andera Partners, EQT Life Sciences, RA Capital Management, and Versant Ventures.
- Series B
- 43 employees
- Founded 2019
10
Marea Therapeutics· San Francisco, California, United States
Marea Therapeutics is a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardio-endocrine diseases. The company’s lead program, MAR001, is in Phase 2 clinical development for adults with metabolic dysfunction and high risk for cardiovascular disease. The company is also advancing MAR002 for the treatment of acromegaly.
- Series B
- 43 employees
- Founded 2022

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Find engineers at Series B Biotech companies in San Francisco

Searching for “engineers at top Series B Biotech companies in San Francisco” surfaces this slice of the market. The list above ranks Biotech companies headquartered in San Francisco whose latest disclosed round is Series B, by current headcount, drawn from public LinkedIn and Crunchbase records. With 19 matching companies in Refolk’s index, this is a tight read on where the Biotech talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series B, Biotech, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become Biotech’s next operators and angel investors.

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Refolk pulled Biotech companies headquartered in San Francisco whose latest disclosed funding round is Series B from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes once a day.

Last refreshed: Wed, 05 Aug 2026 16:58:09 GMT

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