Series C Healthtech companies in San Francisco

Companies building software and devices for clinicians, patients, and payers. Filtered to Series C-stage companies headquartered in San Francisco.

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Built from a search like: “Top Series C Healthtech companies in San Francisco”

Ranked by current headcount across Series C Healthtech companies in San Francisco. Refreshed monthly.

1
SmithRx· San Francisco, Minnesota, United States
Our mission is to reduce the cost and complexity of pharmacy benefits for America’s employers and patients. Pharmacy benefits are broken. The overly complex monopolies built by big PBMs only serve their bottom lines. SmithRx is a transparent, pass-through pharmacy benefits manager for self-insured employers. We operate independently from insurance companies and pharmacies so that our incentives are 100% aligned with our customers. Our modern technology and innovative cost savings programs connect our members to the lowest cost drugs.Get in touch with us to today to learn how to save on your pharmacy spend!
- Series C
- 597 employees
- Founded 2016
2
Arine· San Francisco, California, United States
Arine is the leading AI-powered medication optimization platform that improves patient outcomes and reduces healthcare costs by ensuring that patients receive the most effective and appropriate medications. By integrating advanced analytics with deep clinical expertise, Arine provides timely, personalized recommendations, enabling health plans and risk-based provider organizations to enhance medication safety, adherence, and effectiveness among their members.
- Series C
- 370 employees
- Founded 2017
3
Ambience Healthcare· San Francisco, California, United States
Ambience Healthcare is the leading AI platform for documentation, coding, and clinical workflows, built to reduce administrative burden and protect revenue integrity at the point of care. Trusted by top health systems across North America, Ambience’s platform is live across outpatient, emergency, and inpatient settings, supporting more than 100 specialties with real-time, coding-aware documentation. The platform integrates directly with Epic, Oracle Cerner, athenahealth, and other major EHRs. Founded in 2020 by Mike Ng and Nikhil Buduma, Ambience is headquartered in San Francisco and backed by Oak HC/FT, Andreessen Horowitz (a16z), OpenAI Startup Fund, Kleiner Perkins, and other leading investors.For official information or questions on available roles, please visit https://careers.ambiencehealthcare.com
- Series C
- 260 employees
- Founded 2020
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4
Tempo· San Francisco, California, United States
Tempo’s mission is to give everyone the power to realize their strength and lead a healthy, full life. Using 3D sensors and A.I., Tempo enables real-time feedback to expertly correct your form, provide personalized feedback that can track your movements, and use that data to give you a richer and more effective workout in live and on-demand classes.
- Series C
- 219 employees
- Founded 2015
5
SafelyYou· San Francisco, California, United States
Originating in 2015 as the doctoral research of CEO George Netscher—and inspired by his own family's experience with Alzheimer's disease—SafelyYou was spun out of UC Berkeley’s Artificial Intelligence Research Lab, one of the top five AI research groups in the world. The company’s passionate mission is to empower safer, more person-centered dementia care through world-leading, real-time AI video technology and 24/7 remote clinical experts. SafelyYou is used by skilled nursing facilities and assisted living communities all across North America—from the largest national organizations to regional and local ones, too. SafelyYou is one of five most innovative fall technologies referenced in the Senate Falls Report (2019).SafelyYou gives a voice to those living with Alzheimer’s and other forms of dementia. Its AI-video technology sees critical care moments in real-time, detecting on-the-ground events with over 99.5% accuracy. SafelyYou’s remote clinical experts have seen more falls and on-the-ground events than anyone in the world, enabling a level of predictive, person-centered dementia care that was never before possible. SafelyYou is solving a critical problem across senior care and making an impact by reducing falls by 40% and fall-related ER visits by 80%.
- Series C
- 199 employees
- Founded 2015

6
Osso VR· San Francisco, California, United States
Osso VR is an award-winning, clinically validated healthcare training and assessment platform. Our immersive experiences offer a hands-on training environment that leads to real-world performance gains and improved outcomes.
- Series C
- 95 employees
- Founded 2016
7
Sempre Health· San Francisco, California, United States
Sempre Health is bringing behavior-based, individualized copays to healthcare. Today, we work with health plans and pharma manufacturers to dynamically adjust copays based on individual adherence and behavior, seamlessly at the point of fill.Sempre uses behavioral economics and SMS to engage patients over time. For example, if you are adherent and take your medications regularly, you will pay less when filling your prescription. This means you can bring your own costs down over time. Sempre enables long-term behavior change and saves healthcare dollars, while addressing affordability in a unique way.We parse millions of prescription records to predict the right price, for the right patient, at the right time. Then our data integrations deliver that price at any pharmacy in the US. Via SMS, patients have access to their discounts, why they got those discounts and guidance on how to improve their health.
- Series C
- 27 employees
- Founded 2015
8
Arterys (Acquired by Tempus AI)· San Francisco, California, United States
Arterys was founded to facilitate the global advancement of medicine through data, artificial intelligence and technology. Because a significant proportion of the world's medical data resides in medical images, Arterys set out to tackle several issues around the space, including the enormous workloads radiologists face, the lack of accuracy with many of today's tools, and the need for increased consistency across practices. The company was the first to receive FDA clearance for a cloud-based product with Artificial Intelligence, and currently has 8 FDA clearances, and is active in 118 countries. Arterys continues to focus on solving some of radiology's most pressing needs. We deliver the most comprehensive set of clinical AI solutions in the industry, built off a single platform and user interface that focuses on users with seamless workflow integration and a unified and optimized UI for every one of our applications. By making imaging diagnostics quantitative, intelligent and available, we empower healthcare organizations to improve physicians’ experience, patient outcomes, efficiency, and reduce costs with cloud and AI. Arterys has offices in San Francisco, Calgary and Paris. For more information, please visit www.arterys.com. Follow Arterys on Twitter at @ArterysInc at https://twitter.com/ArterysInc.
- Series C
- 13 employees
- Founded 2013

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Find engineers at Series C Healthtech companies in San Francisco

Searching for “engineers at top Series C Healthtech companies in San Francisco” surfaces this slice of the market. The list above ranks Healthtech companies headquartered in San Francisco whose latest disclosed round is Series C, by current headcount, drawn from public LinkedIn and Crunchbase records. With 8 matching companies in Refolk’s index, this is a tight read on where the Healthtech talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series C, Healthtech, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become Healthtech’s next operators and angel investors.

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Refolk pulled Healthtech companies headquartered in San Francisco whose latest disclosed funding round is Series C from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Fri, 18 Sep 2026 07:48:23 GMT

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