Series C Healthtech companies in San Francisco

Companies building software and devices for clinicians, patients, and payers. Filtered to Series C-stage companies headquartered in San Francisco.

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Built from a search like: “Top Series C Healthtech companies in San Francisco”

Ranked by current headcount across Series C Healthtech companies in San Francisco. Refreshed monthly.

1
Future· San Francisco, California, United States
Future is building a personalized health platform that makes concierge-level care accessible to everyone. Members are paired with real coaches who develop plans that evolve with your goals, progress, and health signals. Starting with fitness, we're now expanding into a broader system for lifelong health, across movement, nutrition, sleep, supplementation, and preventative care. Get early access: future.co/health
- Series C
- 805 employees
- Founded 2021
2
Octave· San Francisco, California, United States
At Octave, we envision a future where premium mental health care isn’t a luxury. That’s why we’re creating a new standard for care that’s sustainable for providers and accessible for patients.We partner with clients to develop customized and evidence-based care plans — not "one-size-fits-all" solutions — that are covered by their insurance. This approach helps people experience profound change that is just as measurable as it is meaningful.We also built WiseMatch, a technology platform that surfaces the right provider fit at the right time and enables seamless booking with that provider wherever you look for one. Learn more about WiseMatch at https://www.wisematch.com/.If you’re passionate about high-quality mental health care and ready to help us change the future of how people feel, you’re in the right place. Learn more at https://findoctave.com/careers-overview.
- Series C
- 629 employees
- Founded 2018
3
SmithRx· San Francisco, California, United States
Our mission is to reduce the cost and complexity of pharmacy benefits for America’s employers and patients. Pharmacy benefits are broken. The overly complex monopolies built by big PBMs only serve their bottom lines. SmithRx is a transparent, pass-through pharmacy benefits manager for self-insured employers. We operate independently from insurance companies and pharmacies so that our incentives are 100% aligned with our customers. Our modern technology and innovative cost savings programs connect our members to the lowest cost drugs.Get in touch with us to today to learn how to save on your pharmacy spend!
- Series C
- 615 employees
- Founded 2016
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4
Two Chairs· San Francisco, California, United States
We’re building a world where everyone has access to exceptional mental health care.Two Chairs is setting a new care standard with seamlessly integrated therapy and psychiatry that’s delivered by highly trained clinicians, powered by smart technology, and measured for real impact. We combine fast access, personalized care, and proven outcomes to create a system that actually works — for patients, providers, health plans, and clinicians alike. Learn more at twochairs.com.
- Series C
- 613 employees
- Founded 2017
5
Brightside Health· San Francisco, California, United States
Brightside Health delivers life-changing mental health care to people with mild to severe clinical depression, anxiety, and other mood disorders, including those with elevated suicide risk. Powered by proprietary AI, purpose-built technology, and a world-class clinician network, Brightside Health combines precision psychiatry and leading-edge therapeutic techniques to offer timely care and improve patient outcomes across the entire clinical spectrum, affordably and at scale. Brightside Health accepts insurance in all 50 states and DC, covering 130+ million lives with Cigna / Evernorth, Aetna, UnitedHealthcare / Optum, and more. Members can also pay for services out-of-pocket.
- Series C
- 474 employees
- Founded 2017

6
Arine· San Francisco, California, United States
Arine is the leading AI-powered medication optimization platform that improves patient outcomes and reduces healthcare costs by ensuring that patients receive the most effective and appropriate medications. By integrating advanced analytics with deep clinical expertise, Arine provides timely, personalized recommendations, enabling health plans and risk-based provider organizations to enhance medication safety, adherence, and effectiveness among their members.
- Series C
- 371 employees
- Founded 2017
7
Ambience Healthcare· San Francisco, California, United States
Ambience Healthcare is the leading AI platform for documentation, coding, and clinical workflows, built to reduce administrative burden and protect revenue integrity at the point of care. Trusted by top health systems across North America, Ambience’s platform is live across outpatient, emergency, and inpatient settings, supporting more than 100 specialties with real-time, coding-aware documentation. The platform integrates directly with Epic, Oracle Cerner, athenahealth, and other major EHRs. Founded in 2020 by Mike Ng and Nikhil Buduma, Ambience is headquartered in San Francisco and backed by Oak HC/FT, Andreessen Horowitz (a16z), OpenAI Startup Fund, Kleiner Perkins, and other leading investors.For official information or questions on available roles, please visit https://careers.ambiencehealthcare.com
- Series C
- 260 employees
- Founded 2020
8
Tempo· San Francisco, California, United States
Tempo’s mission is to give everyone the power to realize their strength and lead a healthy, full life. Using 3D sensors and A.I., Tempo enables real-time feedback to expertly correct your form, provide personalized feedback that can track your movements, and use that data to give you a richer and more effective workout in live and on-demand classes.
- Series C
- 219 employees
- Founded 2015
9
SafelyYou· San Francisco, California, United States
Originating in 2015 as the doctoral research of CEO George Netscher—and inspired by his own family's experience with Alzheimer's disease—SafelyYou was spun out of UC Berkeley’s Artificial Intelligence Research Lab, one of the top five AI research groups in the world. The company’s passionate mission is to empower safer, more person-centered dementia care through world-leading, real-time AI video technology and 24/7 remote clinical experts. SafelyYou is used by skilled nursing facilities and assisted living communities all across North America—from the largest national organizations to regional and local ones, too. SafelyYou is one of five most innovative fall technologies referenced in the Senate Falls Report (2019).SafelyYou gives a voice to those living with Alzheimer’s and other forms of dementia. Its AI-video technology sees critical care moments in real-time, detecting on-the-ground events with over 99.5% accuracy. SafelyYou’s remote clinical experts have seen more falls and on-the-ground events than anyone in the world, enabling a level of predictive, person-centered dementia care that was never before possible. SafelyYou is solving a critical problem across senior care and making an impact by reducing falls by 40% and fall-related ER visits by 80%.
- Series C
- 199 employees
- Founded 2015
10
Osso VR· San Francisco, California, United States
Osso VR is an award-winning, clinically validated healthcare training and assessment platform. Our immersive experiences offer a hands-on training environment that leads to real-world performance gains and improved outcomes.
- Series C
- 95 employees
- Founded 2016

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Find engineers at Series C Healthtech companies in San Francisco

Searching for “engineers at top Series C Healthtech companies in San Francisco” surfaces this slice of the market. The list above ranks Healthtech companies headquartered in San Francisco whose latest disclosed round is Series C, by current headcount, drawn from public LinkedIn and Crunchbase records. With 12 matching companies in Refolk’s index, this is a tight read on where the Healthtech talent in San Francisco is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series C, Healthtech, in San Francisco - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become Healthtech’s next operators and angel investors.

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Refolk pulled Healthtech companies headquartered in San Francisco whose latest disclosed funding round is Series C from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Thu, 29 Oct 2026 08:47:30 GMT

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