Series A Biotech companies in Boston

Companies applying biology, chemistry, and computation to therapeutics and tooling. Filtered to Series A-stage companies headquartered in Boston.

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Ranked by current headcount across Series A Biotech companies in Boston. Refreshed monthly.

1
Kelonia Therapeutics· Boston, Massachusetts, United States
Kelonia is pioneering a new wave of genetic medicines using its next generation gene delivery platform. The company’s simple and elegant cutting-edge in vivo gene delivery technology uses a few potent lentiviral vector-like particles to precisely and efficiently deliver in vivo genetic cargo to the desired target tissue, and only that tissue, every time. With an initial focus on developing transformational therapies for solid tumors and hematologic cancers, Kelonia is building a pipeline of genetic medicines for a wide range of diseases, with the bold goal of bringing genetic medicines to every patient in need.
- Series A
- 60 employees
- Founded 2017
2
Protein Metrics, LLC· Boston, Massachusetts, United States
Protein Metrics' vendor-neutral software allows scientists to use data generated on analytical instruments like mass spectrometers to quickly identify and report protein sequences as well as any variations from the expected form. We innovate so that biopharmaceutical companies and university research labs can achieve confident results from their analysis and reporting. With our customers, we are boldly advancing protein characterization. For more information, visit http://www.proteinmetrics.com.
- Series A
- 56 employees
- Founded 2011
3
Spear Bio· Boston, Massachusetts, United States
Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts. Spear Bio’s proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), employs a unique 2-factor authentication mechanism to precisely measure protein biomarkers at attomolar levels from sub-microliter sample volumes, enabling unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring, empowering clinicians and researchers to improve patient outcomes, and advance global health.For more information, please visit www.spear.bio or email info@spear.bio.
- Series A
- 54 employees
- Founded 2021
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4
Delve Bio· Boston, Massachusetts, United States
We are a well-funded biotech company backed by some of the most experienced operators and investors in the biotech industry. Our co-founders are highly experienced researchers, clinicians, and entrepreneurs, on a mission to improve precision medicine with cutting-edge genomic technology.
- Series A
- 43 employees
- Founded 2022
5
Dash Bio· Boston, Massachusetts, United States
At Dash Bio, we're revolutionizing bioanalysis to expedite drug development. By leveraging robotics and modern software, we deliver higher-quality assays with turnaround times up to 10x faster than the industry average, scaling seamlessly from preclinical through late-stage clinical studies.While drug discovery has been revolutionized with AI and breakthrough modalities, the development phase remains bogged down by manual, labor-intensive processes. We're changing that narrative. Our tech-first products automate critical steps, reducing costs and time to market while improving quality of results.Meet Our Leadership Team:Dave Johnson, CEO: Former Chief Data and AI Officer at Moderna.Ander Tallett, COO: Led Enterprise Systems at Moderna and Resilience.Ely Porter, CSO: Co-founder and CTO of Rootpath.Together, we're crafting a future where bioanalysis is intuitive, data flows effortlessly, and drugs reach the market faster than ever before.Join us on this journey. Learn more at dash.bio
- Series A
- 43 employees
- Founded 2024

6
Magnet Biomedicine· Boston, Massachusetts, United States
Magnet Biomedicine is a biotechnology company advancing molecular glue discovery with rational selection and design. We are reimagining what is achievable with molecular glues by looking beyond known protein–protein interactions and analyzing the broad protein landscape to pair target proteins with rationally selected presenter proteins to drive therapeutic effects. Our TrueGlueTM discovery platform applies cutting-edge advancements in human biology and proteomics to identify fit-for-purpose glues that offer category-leading benefits and maximize therapeutic impact.
- Series A
- 42 employees
- Founded 2019
7
AI Proteins· Boston, Massachusetts, United States
Boston-based AI Proteins is a biotech company on a mission to re-imagine protein therapeutics with a novel approach for designing entirely new proteins. Using AI-enabled design and a high-throughput drug discovery platform, AI Proteins creates de novo miniproteins optimized for a variety of therapeutic applications. Partnered with leading biopharmaceutical companies, AI Proteins continues to pursue collaborations across a wide variety of therapeutic areas in addition to advancing its internal pipeline. The AI Proteins platform can dramatically accelerate the development of lead therapeutic candidates ready for IND-enabling studies.
- Series A
- 39 employees
- Founded 2021
8
Genialis· Boston, Massachusetts, United States
Genialis provides therapeutic intelligence with its Supermodel of cancer biology. We develop and validate clinically actionable AI models informed by the world’s most ethnographically diverse cancer data sets to predict patient responses and guide treatment decisions for targeted inhibitors, immunotherapies, and other emerging therapeutic classes. Genialis is trusted by pharma and diagnostics partners, and together, we are transforming medicine through data.The company is headquartered in Houston, Boston and Ljubljana.
- Series A
- 31 employees
- Founded 2015
9
Newleos Therapeutics· Boston, Massachusetts, United States
We are dedicated to providing a new dawn or "eos" for patients with mental health conditions by developing next generation, first- and best-in-class therapies. Over 100 million patients in the United States are affected by neuropsychiatric disorders, with anxiety and substance use disorders among the largest areas of unmet medical need. Our clinical-stage pipeline was licensed from Roche and includes oral small molecules targeting GABAA-γ1, V1a, TAAR1 and GABAA-α5 with broad potential in general anxiety, social anxiety, substance use disorders and cognitive impairment. Newleos was co-founded by Longwood Fund, Federico Bolognani, M.D., Ph.D., and William Martin, Ph.D., seasoned experts in company creation and CNS drug development.
- Series A
- 29 employees
- Founded 2024
10
DeepCure· Boston, Massachusetts, United States
DeepCure discovers transformative small molecule therapies for immune and inflammatory diseases. The company uses a chemistry platform that combines AI with advanced physics-based tools to identify truly novel molecules that address unsolved challenges in drug discovery. The pipeline includes an oral STAT6 program with multiple novel scaffolds and an oral BRD4(BD2) program with the first truly selective inhibitor. DeepCure expects to start in clinical trials in 2026.
- Series A
- 28 employees
- Founded 2018

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Find engineers at Series A Biotech companies in Boston

Searching for “engineers at top Series A Biotech companies in Boston” surfaces this slice of the market. The list above ranks Biotech companies headquartered in Boston whose latest disclosed round is Series A, by current headcount, drawn from public LinkedIn and Crunchbase records. With 29 matching companies in Refolk’s index, this is a tight read on where the Biotech talent in Boston is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series A, Biotech, in Boston - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become Biotech’s next operators and angel investors.

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Refolk pulled Biotech companies headquartered in Boston whose latest disclosed funding round is Series A from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Tue, 20 Oct 2026 20:32:17 GMT

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