Series B AI companies in New York

Companies building AI products, foundation models, and applied ML platforms. Filtered to Series B-stage companies headquartered in New York.

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Built from a search like: “Top Series B AI companies in New York”

Ranked by current headcount across Series B AI companies in New York. Refreshed monthly.

1
Immunai· New York, New York, United States
Comprehensively mapping and decoding the immune system with single-cell biology and AI to power new therapeutic discoveries, accelerate drug development and improve patient outcomes
- Series B
- 173 employees
- Founded 2019
2
Lifebit· New York, New York, United States
Lifebit powers the federated infrastructure behind national-scale biomedical research. Our platform enables pharma, biobanks, and governments to analyze the world's most sensitive health data — without the data ever leaving its source.Genomics England runs on Lifebit. So do ten of the world's largest biobanks, and research programs spanning the UK, US, and Asia.We built the federated Trusted Research Environment (TRE) from first principles around the ONS Five Safes framework: data stays at source, sovereignty stays with the data controller, and every output passes through an airlock. It's what makes population-scale genomics, federated multi-omic analysis, and cross-border biomedical AI possible without compromising patient trust.For the pharma companies accelerating discovery. For the biobanks safeguarding a generation of consented data. For the governments treating health data as sovereign infrastructure — Lifebit is the operating layer.
- Series B
- 67 employees
- Founded 2017
3
Hume AI· New York, New York, United States
Built from a decade of voice and emotion research.To build emotionally intelligent voice AI, we first had to define what “good” sounds like – not just acoustically, but perceptually and in real human conversations.That led us to build the research infrastructure behind expressive, trustworthy voice AI: scientifically grounded datasets, speech models, evaluation frameworks, and human preference pipelines. Today, we make that infrastructure available to frontier labs and AI-native companies building the next generation of voice.Whether you’re building foundation models, fine-tuning voice agents, or evaluating production systems, Hume provides the tools to measure, improve, and align voice AI the way people actually experience them.
- Series B
- 55 employees
- Founded 2021
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4
HowGood· Stone Ridge, New York, United States
HowGood is an independent research company and SaaS data platform with the worlds largest database on food product sustainability. With more than 90,000 on-farm emissions factors for food ingredients, HowGood helps leading brands, retailers, suppliers and restaurants to measure, manage, and communicate their environmental and social impact.
- Series B
- 51 employees
- Founded 2007
5
Helaina· New York, New York, United States
Helaina is a biotech company pushing the boundaries of what food can do for health.
- Series B
- 50 employees
- Founded 2019

6
Envisagenics· Long Island City, New York, United States
Envisagenics was founded in 2014 as a spinout of Cold Spring Harbor Laboratory. Our mission is to reduce the complexity of biomedical data to accelerate the development of innovative therapeutic solutions through RNA splicing analytics and artificial intelligence. We focus on the discovery of RNA therapeutics. Over 30 million people in the US suffer from genetic diseases or cancer that could be caused by mutations affecting RNA splicing. 370 human diseases are known to be caused by splicing errors, and more remain to be discovered.Our breakthrough technology, SpliceCore, is a cloud-based platform that is experimentally validated to predict drug targets and biomarkers through splicing discovery from RNA-seq data, using Artificial Intelligence. We are using our software to identify splicing errors causative of diseases, identify the right drug-targets and develop RNA therapeutics through partnerships and collaborations with Biopharma. Our in-silico RNA therapeutics discovery platform replaces expensive drug-target selection and lead design with efficient computer simulations, decreasing time, cost, and failure risk of drug development programs.
- Series B
- 33 employees
- Founded 2014
7
HiberCell· New York, New York, United States
HiberCell is a clinical stage oncology company, dedicated to the advancement of first-in-class agents with the novel MOA of modulation of adaptive stress pathways and anti-tumor immunity. We believe that therapeutic modulation of these mechanisms allows us to address tumor metastasis, treatment resistance, and cancer relapse; all significant drivers of cancer-related deaths. Our product candidates HC-5404 and HC-7366, both completing Phase 1a clinical trials, target the stress response kinases PERK and GCN2, respectively, while our product candidate odetiglucan, currently in Phase 2 clinical development, modulates the anti-tumor innate immune response.
- Series B
- 25 employees
- Founded 2019
8
AnHeart Therapeutics· New York, New York, United States
AnHeart is now a Nuvation Bio company. For the latest news and updates please visit www.linkedin.com/company/nuvationbio/
- Series B
- 17 employees
- Founded 2018
9
Intrommune Therapeutics· New York, New York, United States
Intrommune Therapeutics, Inc. is a biotechnology company located in New York, NY. Intrommune is developing food allergy immunotherapies that are delivered while you brush your teeth, a lifelong habit that is ingrained in most people and ensures daily use of our product. Intrommune's elegant new treatment platform for food allergies is expected to be safe, effective and convenient. Intrommune’s first product is a therapy for patients who suffer from peanut allergy.Intrommune is developing the oral mucosal immunotherapy (OMIT) platform for food allergies. It is a long-term solution for the 220 million, including 32 million people in the U.S., who suffer from this life-altering condition.
- Series B
- 14 employees
- Founded 2015
10
Treadwell Therapeutics, Inc.· New York, New York, United States
Treadwell Therapeutics is a clinical-stage biotechnology company developing novel therapeutics for highly aggressive cancers by targeting critical tumor-specific vulnerabilities including aneuploidy and immunogenicity. The Company’s robust, internally developed pipeline includes novel small molecule drugs in single agent and combination studies. Lead candidate, CFI-400945, is a PLK4 inhibitor in multiple Phase 1 and Phase 2 trials including for TNBC, prostate cancer and AML. Additional product candidates include CFI-402257, a clinical stage TTK inhibitor, as well as CFI-402411, a preclinical HPK1 inhibitor (IND filing 1H20), which is positioned to be the first clinical stage small molecule modulator of a unique node of T cell activation and has a mechanism distinct from PD1/PDL1. Interested in joining Treadwell Therapeutics? Visit our Career page: https://treadwelltx.com/careers/
- Series B
- 12 employees
- Founded 2019

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Find engineers at Series B AI companies in New York

Searching for “engineers at top Series B AI companies in New York” surfaces this slice of the market. The list above ranks AI companies headquartered in New York whose latest disclosed round is Series B, by current headcount, drawn from public LinkedIn and Crunchbase records. With 14 matching companies in Refolk’s index, this is a tight read on where the AI talent in New York is heating up.

Three filters at once narrows the field hard. The companies that survive all three - Series B, AI, in New York - are usually the most targeted recruiting pool a hiring manager can ask for. Senior engineers, founding designers, and product leads here are about to become AI’s next operators and angel investors.

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Refolk pulled AI companies headquartered in New York whose latest disclosed funding round is Series B from public LinkedIn and Crunchbase records, ranked them by current employee count, and kept those with at least 3 employees. The list refreshes monthly.

Last refreshed: Thu, 22 Oct 2026 19:07:56 GMT

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