Principal Lab Automation Engineer

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor - all in service of patients.

The Opportunity:

RevMed is seeking a Senior/Principal Lab Automation Engineer to join Platform Sciences and Automation (PSA) team within the Sample Management and Screening Platform Technologies (SM-SPT) function. You will bring deep automation expertise and a hands-on builder mindset to develop flexible systems, support reliable sample management and assay operations, and advance digital integration across Research. Working closely with scientists, engineers, research operations, and data and informatics teams, you will help build a nimble automation ecosystem that enables rapid adaptation and deployment of evolving scientific workflows through reusable laboratory capabilities. This role requires onsite presence at our Redwood City headquarters.

Key Responsibilities

• Translate scientific needs into automation. Partner closely with scientific teams to define and prioritize workflows, establish process-specific QC metrics, and implement reliable automated processes.

• Build reusable capabilities. Design, develop, integrate, and qualify workcells, liquid-handling systems, and protocols with the modularity and flexibility needed for rapid deployment across processes and technologies.

• Support reliable operations. Provide hands-on method development, optimization, and troubleshooting for standalone and integrated systems supporting both sample management and assay operations.

• Own digital automation and integration. Partner with research leadership, SM-SPT teams, IT, informatics, data engineering, and software teams to build digital products and drive LIMS integrations. Connect scientific intent, experimental planning, automated execution, and contextual data capture with downstream analytics and AI/ML to enable faster learning cycles.

• Shape strategy and investment. Collaboratively define near- and long-term physical and digital automation needs, align the roadmap with leadership, and guide internal development, build-versus-buy, and investment decisions. Evaluate emerging screening, assay technologies or data solutions for scientific impact within SM-SPT and across RevMed Research.

• Develop people and operational best practices. Work alongside and mentor engineers and operators through installation, testing, process validation, and continuous improvement. Drive documentation and training to strengthen business continuity, open communication, and shared accountability.

Required Skills, Experience and Education:

• Bachelor’s degree or higher in engineering, a scientific discipline, or a related field.

• Relevant, hands-on biotech/pharma lab automation experience: BS with 10-12+ years, or MS with 8-10+ years

• Deep knowledge of the lab automation landscape, with demonstrated technical depth across systems of varying scale and a track record of delivering commercial or custom hardware or data automation solutions appropriate to scientific needs.

• Proficiency in sample management or assay operations instrumentation, systems development, and programming across commercial, custom, or open-source platforms - for example, High Res Bio Cellario, Mosaic, Hamilton Verso, Beckman Tempo, Hamilton Venus, Tecan Fluent, PyLabRobot, and Benchling.

• Hands-on LIMS integration experience to streamline and automate sample management and assay data flows.

• Ability to independently own and deliver complex automation initiatives while guiding colleagues in daily work.

• Excellent proactive stakeholder engagement, communication, and organizational skills, with a can-do, can-learn, hands-on builder mindset and a sense of urgency.

Preferred Skills:

• Hands-on custom automation integration experience, with the ability to build and troubleshoot beyond vendor-provided solutions.

• Working knowledge of HTS and biochemical, cellular, or biophysical DMTA assay workflows, including small-molecule compound management, TR-FRET, high-throughput transfection, high-content imaging, or mass spectrometry assays.

• Experience applying state-of-the-art LLM or agentic AI tools to custom data and automation workflows to improve operational efficiency, deployment speed, and user adoption.

#LI-SB1 #LI-Onsite

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range$211,000-$264,000 USD

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