Director, Molecular Pathology, Translational Sciences, Translational Research.

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor - all in service of patients.

The Opportunity:

As a Director, Molecular Pathology, you will be a key member of a cross-functional Translational Sciences Team, reporting to the Senior Director and Head of Translational Sciences within Translational Research and will:

• Biomarker Strategy: Define and execute molecular and digital pathology-driven biomarker strategies.

• Integration of Advanced Modalities: Lead adoption of molecular pathology and spatial technologies (to support translational research and broader BDR needs.

• Digital & Computational Pathology: Drive implementation of whole-slide imaging, AI/ML-based image analysis, and integration of spatial biomarker analytics into decision-making.

• Data Interpretation & Reporting: Provide expert interpretation of pathology data, ensuring robust correlation with clinical outcomes and mechanistic insights.

• Cross-functional Leadership: Collaborate with Translational Medicine, Bioinformatics, and Clinical Development colleagues to implement candidate biomarkers into Translational Biomarker plans for RAS(ON) inhibitors in alignment with overarching clinical development strategies.

Responsibilities

• Scientific Leadership & Execution: Perform and interpret multiplex spatial biomarker datasets to inform Translational hypotheses and clinical strategies. Establish QC standards for data acquisition and analysis.

• Cross-Functional Collaboration: Partner within Research and Clinical teams to integrate spatial biomarker findings into translational plans. Collaborate with Systems Biology and Information Sciences teams to enable visualization tools

• External Partnership Management: Serve as primary scientific liaison to CROs for spatial biomarker workflows; review deliverables, troubleshoot issues, and drive continuous improvement.

• Capability Building: Document best practices and SOPs for spatial biomarker workflows; recommend platform upgrades and pilot evaluations.

Required Skills, Experience & Education:

• 10+ years in digital pathology/spatial biology within pharma, biotech, or CRO settings.

• Scientific Expertise: Deep knowledge of spatial biology (e.g. spatial transcriptomics, Visium, Xenium, GeoMx, MerFish, etc.); ability to translate complex data into actionable insights

• Execution Excellence: Bias for action; delivers high-quality analyses under tight timelines

• Collaboration & Influence: Builds strong relationships across functions and with external partners; communicates clearly and persuasively.

• Innovation & Continuous Improvement: Identifies opportunities to enhance workflows and adopt emerging technologies.

• PhD/MD or equivalent in Cancer Biology, Translational Sciences, Pathology or related discipline.

Preferred Skills:

• Hands-on experience with spatial pathology workloads.

• Familiarity with AI/ML-assisted pathology workflows and spatial statistics.

• Proven ability to manage CRO relationships and deliver time-sensitive biomarker analyses.

#LI-Hybrid #LI-LN1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range$211,000-$264,000 USD

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