Director, Data Management

The Opportunity

Join us at Maze Therapeutics as our Director of Data Management, where you will play a key role in shaping the data strategy that supports our clinical development programs. You’ll partner closely with Biostatistics, Statistical Programming, Clinical Operations, and Regulatory Affairs, and oversee external vendors to deliver high-quality, reliable clinical data across our studies.

Reporting to the Vice President of Biometrics, you’ll provide strategic direction and hands-on leadership for clinical data management activities spanning multiple clinical trials. Your work will ensure timely, compliant, and analysis-ready data that supports regulatory submissions and key program decisions.

The Impact You’ll Have

• Lead data management activities across multiple clinical studies and development phases.
• Shape and implement data management strategies, standards, and best practices.
• Mentor and support data management team members, fostering growth and knowledge sharing.
• Serve as a subject matter expert for data management processes, systems, and regulatory expectations.
• Oversee critical study deliverables including DMPs, CRFs/eCRFs, edit checks, and database locks.
• Guide accurate, consistent, and timely clinical data collection, cleaning, and reconciliation.
• Review and approve key study documentation and ensure readiness for analysis and reporting.
• Drive database lock planning and partner closely with Biostatistics and Medical Writing to support analyses and study reports.
• Manage CROs and external vendors, ensuring clarity around timelines, quality expectations, and contractual commitments.
• Support the evaluation, implementation, and optimization of EDC and data management technologies.
• Collaborate closely with Clinical Operations, Biostatistics, and other partners across the organization.
• Provide data management insights for protocols, study design, and operational planning, while proactively communicating risks and mitigation strategies to senior leadership.

As a Director, we also expect you to demonstrate the following Leadership Competencies:

• Communication and Influence
• Builds communication channels across Maze for sharing information.
• Influences Senior Management decisions through persuasive arguments.
• Respectfully addresses differing opinions leading to support of decisions.

What We’re Looking For

• Bachelor’s or advanced degree in Life Sciences, Computer Science, or related field
• 8+ years of clinical data management experience in biotech, pharmaceutical, or CRO environments
• 3+ years of people and/or project leadership experience
• Hands-on experience with EDC systems (e.g., Medidata Rave, Oracle InForm)
• Strong understanding of clinical trial operations, data flows, and regulatory expectations
• Collaborative, mentorship-oriented leadership stylewith the ability to influence across teams

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together - Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed - We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True - Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $232,000 - $284,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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